PMID- 22155425
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20161125
IS  - 1879-1514 (Electronic)
IS  - 0166-445X (Linking)
VI  - 106-107
DP  - 2012 Jan 15
TI  - Persistent effects on adult swim performance and energetics in zebrafish 
      developmentally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
PG  - 131-9
LID - 10.1016/j.aquatox.2011.11.001 [doi]
AB  - TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) remains a potent and persistent 
      toxicant in aquatic environments, causing lethal developmental deformities in 
      fish. However, few studies have examined sublethal or persistent effects of 
      developmental TCDD exposure and none have examined its effects on swimming 
      capabilities in sub-adult fish. The objective of the current study was to examine 
      whether effects of TCDD exposure during the critical period of cardiovascular 
      development (2-4 days post fertilization) on swim performance, triglyceride 
      stores and cardiovascular deformities would persist until adulthood in zebrafish. 
      Zebrafish larvae were exposed between 48 and 96 h post fertilization to 1, 0.1, 
      0.01 ng/L TCDD or DMSO control (0.005%), then raised in clean water for 90 days. 
      Despite having equal survivability, no significant increase in gross deformities 
      and no change in cytochrome P450 1A (CYP1A) activity was observed, while critical 
      swimming speed and dorsal aorta diameter were significantly decreased in 
      TCDD-exposed fish at 90 days. Furthermore, whole body triglycerides were 
      significantly elevated in TCDD-exposed fish both before and after swim testing. 
      Therefore sublethal TCDD exposure during zebrafish development caused a 
      persistent decrease in swim endurance. The cause of this persistent decrease in 
      swim endurance is not known, but may be related to behavioral adaptations 
      limiting swimming capabilities, failure to mobilize triglyceride stores, vascular 
      deformities limiting blood flow to the periphery, or a combination of these 
      factors.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Marit, Jordan S
AU  - Marit JS
AD  - Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, SK, Canada 
      S7N 5B4.
FAU - Weber, Lynn P
AU  - Weber LP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111109
PL  - Netherlands
TA  - Aquat Toxicol
JT  - Aquatic toxicology (Amsterdam, Netherlands)
JID - 8500246
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Water Pollutants, Chemical)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
SB  - IM
MH  - Animals
MH  - Cytochrome P-450 CYP1A1/metabolism
MH  - Embryo, Nonmammalian/drug effects/physiology
MH  - Female
MH  - Male
MH  - Polychlorinated Dibenzodioxins/*toxicity
MH  - Swimming/*physiology
MH  - Water Pollutants, Chemical/*toxicity
MH  - Zebrafish/*embryology/physiology
EDAT- 2011/12/14 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/06/16 00:00 [received]
PHST- 2011/10/29 00:00 [revised]
PHST- 2011/11/03 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - S0166-445X(11)00304-3 [pii]
AID - 10.1016/j.aquatox.2011.11.001 [doi]
PST - ppublish
SO  - Aquat Toxicol. 2012 Jan 15;106-107:131-9. doi: 10.1016/j.aquatox.2011.11.001. 
      Epub 2011 Nov 9.