PMID- 22156460
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20111213
IS  - 0001-5547 (Print)
IS  - 0001-5547 (Linking)
VI  - 55
IP  - 6
DP  - 2011
TI  - Spectrum of risk of malignancy in subcategories of 'atypia of undetermined 
      significance'.
PG  - 518-25
LID - 10.1159/000333232 [doi]
AB  - OBJECTIVE: To determine if focal 'nuclear atypia' or 'microfollicular 
      architecture' portends a higher risk of malignancy than other subcategories of 
      atypia of undetermined significance (AUS) in thyroid fine-needle aspirations 
      (FNAs). STUDY DESIGN: The frequencies of The Bethesda System for Reporting 
      Thyroid Cytopathology (TBSRTC) categories were calculated from 3,956 thyroid FNAs 
      interpreted over a 26-month period at The Johns Hopkins Hospital after adoption 
      of TBSRTC. TBSRTC criteria were applied strictly. The risk of malignancy, 
      specifically for AUS subcategories, was analyzed by cyto-histo correlation. 
      RESULTS: Of the 133 cases diagnosed as AUS, 32% were found to have stageable 
      carcinoma (not incidental microcarcinoma) on resection. When the subset of AUS 
      with 'nuclear atypia' (AUS-N) was separated from other AUS cases, 48% (30/62) of 
      them had stageable carcinoma on resection; of the AUS subset with 
      'microfollicular architecture' (AUS-F), 27% (8/30) were malignant on resection. 
      The 'suspicious for papillary thyroid carcinoma' (SPTC) group maintained a higher 
      risk of malignancy versus AUS-N (relative risk, RR 1.57; 95% CI 1.23-1.81). 
      CONCLUSION: The subcategory of 'nuclear atypia' within AUS indicates a higher 
      risk of malignancy than other subcategories of AUS but has a lower risk of 
      malignancy than SPTC does. Thus, it is an important distinction with potential 
      clinical implications.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Olson, Matthew T
AU  - Olson MT
AD  - Department of Pathology, The Johns Hopkins Hospital, Baltimore, Md., USA.
FAU - Clark, Douglas P
AU  - Clark DP
FAU - Erozan, Yener S
AU  - Erozan YS
FAU - Ali, Syed Z
AU  - Ali SZ
LA  - eng
PT  - Journal Article
DEP - 20111209
PL  - Switzerland
TA  - Acta Cytol
JT  - Acta cytologica
JID - 0370307
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Biopsy, Fine-Needle
MH  - Carcinoma/classification/*diagnosis/*pathology
MH  - Cell Transformation, Neoplastic/*pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Practice Guidelines as Topic
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk
MH  - Terminology as Topic
MH  - Thyroid Gland/*pathology
MH  - Thyroid Nodule/classification/*diagnosis/*pathology
EDAT- 2011/12/14 06:00
MHDA- 2013/08/28 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/06/27 00:00 [received]
PHST- 2011/09/05 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
AID - 000333232 [pii]
AID - 10.1159/000333232 [doi]
PST - ppublish
SO  - Acta Cytol. 2011;55(6):518-25. doi: 10.1159/000333232. Epub 2011 Dec 9.