PMID- 22157544
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 142
IP  - 1
DP  - 2012 Jan
TI  - Green tea extract suppresses NFkappaB activation and inflammatory responses in 
      diet-induced obese rats with nonalcoholic steatohepatitis.
PG  - 57-63
LID - 10.3945/jn.111.148544 [doi]
AB  - Nonalcoholic steatohepatitis (NASH) is characterized by oxidative stress and 
      inflammatory responses that exacerbate liver injury. The objective of this study 
      was to determine whether the antioxidant and antiinflammatory activities of green 
      tea extract (GTE) would protect against NASH in a model of diet-induced obesity. 
      Adult Wistar rats were fed a low-fat (LF) diet or high-fat (HF) diet containing 
      no GTE or GTE at 1% or 2% (HF+2GTE) for 8 wk. The HF group had greater (P </= 0.05) 
      serum alanine (ALT) and aspartate aminotransferases and hepatic lipids than the 
      LF group. Both GTE groups had lower ALT and hepatic lipid than the HF group. In 
      liver and epididymal adipose, the HF group had lower glutathione as well as 
      greater mRNA and protein expression of TNFalpha and monocyte chemoattractant 
      protein-1 (MCP-1) and NFkappaB binding activity than the LF group. Compared to the HF 
      group, the HF+2GTE group had greater glutathione and lower protein and mRNA 
      levels of inflammatory cytokines in both tissues. NFkappaB binding activities at 
      liver and adipose were also lower, likely by inhibiting the phosphorylation of 
      inhibitor of NFkappaB. NFkappaB binding activities in liver and adipose (P </= 0.05; r = 
      0.62 and 0.46, respectively) were correlated with ALT, and hepatic NFkappaB binding 
      activity was inversely related to liver glutathione (r = -0.35). These results 
      suggest that GTE-mediated improvements in glutathione status are associated with 
      the inhibition of hepatic and adipose inflammatory responses mediated by NFkappaB, 
      thereby protecting against NASH.
FAU - Park, Hea Jin
AU  - Park HJ
AD  - Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA.
FAU - Lee, Ji-Young
AU  - Lee JY
FAU - Chung, Min-Yu
AU  - Chung MY
FAU - Park, Young-Ki
AU  - Park YK
FAU - Bower, Allyson M
AU  - Bower AM
FAU - Koo, Sung I
AU  - Koo SI
FAU - Giardina, Charles
AU  - Giardina C
FAU - Bruno, Richard S
AU  - Bruno RS
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111207
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Cytokines)
RN  - 0 (DNA Primers)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 0 (Tea)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cytokines/metabolism
MH  - DNA Primers
MH  - *Diet
MH  - Fatty Liver/*complications
MH  - Male
MH  - NF-kappa B/*antagonists & inhibitors/metabolism
MH  - Non-alcoholic Fatty Liver Disease
MH  - Obesity/complications/*etiology/metabolism
MH  - Phosphorylation
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Real-Time Polymerase Chain Reaction
MH  - Tea/*chemistry
EDAT- 2011/12/14 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - S0022-3166(22)02945-5 [pii]
AID - 10.3945/jn.111.148544 [doi]
PST - ppublish
SO  - J Nutr. 2012 Jan;142(1):57-63. doi: 10.3945/jn.111.148544. Epub 2011 Dec 7.