PMID- 22157617
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20171116
IS  - 1554-6578 (Electronic)
IS  - 0022-3069 (Linking)
VI  - 71
IP  - 1
DP  - 2012 Jan
TI  - Fig4 expression in the rodent nervous system and its potential role in preventing 
      abnormal lysosomal accumulation.
PG  - 28-39
LID - 10.1097/NEN.0b013e31823deda8 [doi]
AB  - The phosphatase FIG4 regulates the concentration of phosphatidylinositol 
      3,5-diphosphate (PI3,5P2), a molecule critical for endosomal/lysosomal membrane 
      trafficking and neuron function. We investigated Fig4 expression in the 
      developing CNS of mice and rats using Western blot, real-time polymerase chain 
      reaction, and morphological techniques in situ and in vitro and after spinal cord 
      injury. Fig4 was expressed at a high levels throughout development in myelinating 
      cells, particularly Schwann cells, and dorsal root ganglia sensory neurons. Fig4 
      protein and mRNA in CNS neurons were markedly diminished in adult versus 
      embryonal animals. Spinal cord hemisection induced upregulation of Fig4 in adult 
      spinal cord tissues that was associated with accumulation of lysosomes in neurons 
      and glia. This accumulation appeared similar to the abnormal lysosomal storage 
      observed in dorsal root ganglia of young fig4-null mice. The results suggest that 
      Fig4 is involved in normal neural development and the maintenance of peripheral 
      nervous system myelin. We speculate that adequate levels of Fig4 may be required 
      to prevent neurons and glia from excessive lysosomal accumulation after injury 
      and in neurodegeneration.
FAU - Guo, Jiasong
AU  - Guo J
AD  - Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA.
FAU - Ma, Yuan-Huan
AU  - Ma YH
FAU - Yan, Qing
AU  - Yan Q
FAU - Wang, Lily
AU  - Wang L
FAU - Zeng, Yuan-Shan
AU  - Zeng YS
FAU - Wu, Jin-Lang
AU  - Wu JL
FAU - Li, Jun
AU  - Li J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
RN  - 0 (Flavoproteins)
RN  - EC 3.1.3.36 (Fig4 protein, mouse)
RN  - EC 3.1.3.36 (Phosphoinositide Phosphatases)
SB  - IM
EIN - J Neuropathol Exp Neurol. 2012 Jun;71(6):601
MH  - Animals
MH  - Cells, Cultured
MH  - Female
MH  - Flavoproteins/*biosynthesis
MH  - Ganglia, Spinal/metabolism/pathology
MH  - *Gene Expression Regulation, Developmental
MH  - Lysosomes/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurodegenerative Diseases/enzymology/metabolism/pathology
MH  - Neuroglia/*metabolism/pathology
MH  - Neurons/*metabolism/pathology
MH  - Phosphoinositide Phosphatases
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord Injuries/metabolism/pathology
EDAT- 2011/12/14 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - 10.1097/NEN.0b013e31823deda8 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 2012 Jan;71(1):28-39. doi: 
      10.1097/NEN.0b013e31823deda8.