PMID- 22159019
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20220310
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 53
IP  - 1
DP  - 2012 Jan 20
TI  - Automated characterization of pigment epithelial detachment by optical coherence 
      tomography.
PG  - 164-70
LID - 10.1167/iovs.11-8188 [doi]
AB  - PURPOSE: To assess the accuracy of automated classification of pigment epithelial 
      detachments (PED) by using a software algorithm applied to spectral-domain 
      optical coherence tomography (SD-OCT) scans. METHODS: HD-OCT (Cirrus; Carl Zeiss 
      Meditec, Dublin, CA) volume scans (512 x 128) were retrospectively collected from 
      46 eyes of 33 patients with evidence of PED in the setting of age-related macular 
      degeneration (AMD, n = 28) or central serous chorioretinopathy (CSCR, n = 5). In 
      these eyes, 168 PEDs were automatically detected with a system-associated tool 
      (Cirrus HD-OCT RPE Elevation Analysis; Carl Zeiss Meditec). Two independent, 
      certified Doheny Image Reading Center (DIRC) OCT graders classified these PEDs 
      into three categories--serous, drusenoid, or fibrovascular--via inspection of the 
      B-scans. Manual classification results served as the gold standard for 
      comparisons with automated classification. For automated classification, 
      interindividual variation in intensities was normalized in all images. Individual 
      A-scans within the detected PEDs were then automatically classified into one of 
      three categories based on the mean internal intensity and the standard deviation 
      of the internal intensity: mean intensity <30 (serous type); mean intensity >/=30 
      but <60 or mean intensity >/=30 and SD >/=30 (fibrovascular type); or mean intensity 
      >/=60 and SD < 30 (drusenoid type). Individual PEDs were then automatically 
      classified into the same three categories based on the predominant type of A-scan 
      within the PED. For mixed PEDs (many A-scans of each type), a risk index for 
      neovascularization was computed based on the percentage of fibrovascular A-scans. 
      In addition, a confidence index was computed for each PED based on its 
      mathematical distance from the PED category boundaries. RESULTS: Among the 168 
      PEDs, the DIRC graders classified 16 as serous, 88 as fibrovascular, and 64 as 
      drusenoid PEDs. The automated algorithm classified 14 as serous, 96 as 
      fibrovascular, and 58 as drusenoid PEDs. The sensitivity and specificity values 
      for automated classification according to type of PED were 88% and 100% for 
      serous, 76% and 64% for fibrovascular, and 58% and 81% for drusenoid, 
      respectively. CONCLUSIONS: Automated classification of PEDs using internal 
      reflectivity characteristics appears to be sensitive for detecting serous and 
      fibrovascular PEDs. Automated classification and quantification of PEDs may be a 
      useful tool in future studies for stratifying PEDs according to risk and possibly 
      predicting the risk of advanced AMD.
FAU - Lee, Sun Young
AU  - Lee SY
AD  - Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the 
      University of Southern California, Los Angeles, California, USA.
FAU - Stetson, Paul F
AU  - Stetson PF
FAU - Ruiz-Garcia, Humberto
AU  - Ruiz-Garcia H
FAU - Heussen, Florian M
AU  - Heussen FM
FAU - Sadda, SriniVas R
AU  - Sadda SR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120120
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Macular Degeneration/*complications/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Retinal Detachment/*classification/diagnosis/etiology
MH  - Retinal Pigment Epithelium/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
EDAT- 2011/12/14 06:00
MHDA- 2012/03/07 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - iovs.11-8188 [pii]
AID - 10.1167/iovs.11-8188 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2012 Jan 20;53(1):164-70. doi: 10.1167/iovs.11-8188.