PMID- 22159127
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 31
IP  - 49
DP  - 2011 Dec 7
TI  - Astrocyte calcium signaling transforms cholinergic modulation to cortical 
      plasticity in vivo.
PG  - 18155-65
LID - 10.1523/JNEUROSCI.5289-11.2011 [doi]
AB  - Global brain state dynamics regulate plasticity in local cortical circuits, but 
      the underlying cellular and molecular mechanisms are unclear. Here, we 
      demonstrate that astrocyte Ca(2+) signaling provides a critical bridge between 
      cholinergic activation, associated with attention and vigilance states, and 
      somatosensory plasticity in mouse barrel cortex in vivo. We investigated first 
      whether a combined stimulation of mouse whiskers and the nucleus basalis of 
      Meynert (NBM), the principal source of cholinergic innervation to the cortex, 
      leads to enhanced whisker-evoked local field potential. This plasticity is 
      dependent on muscarinic acetylcholine receptors (mAChR) and N-methyl-d-aspartic 
      acid receptors (NMDARs). During the induction of this synaptic plasticity, we 
      find that astrocytic [Ca(2+)](i) is pronouncedly elevated, which is blocked by 
      mAChR antagonists. The elevation of astrocytic [Ca(2+)](i) is crucial in this 
      type of synaptic plasticity, as the plasticity could not be induced in 
      inositol-1,4,5-trisphosphate receptor type 2 knock-out (IP(3)R2-KO) mice, in 
      which astrocytic [Ca(2+)](i) surges are diminished. Moreover, NBM stimulation led 
      to a significant increase in the extracellular concentration of the NMDAR 
      coagonist d-serine in wild-type mice when compared to IP(3)R2-KO mice. Finally, 
      plasticity in IP(3)R2-KO mice could be rescued by externally supplying d-serine. 
      Our data present coherent lines of in vivo evidence for astrocytic involvement in 
      cortical plasticity. These findings suggest an unexpected role of astrocytes as a 
      gate for cholinergic plasticity in the cortex.
FAU - Takata, Norio
AU  - Takata N
AD  - Laboratory for Neuron Glia Circuit and Laboratory for Developmental Neurobiology, 
      RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.
FAU - Mishima, Tsuneko
AU  - Mishima T
FAU - Hisatsune, Chihiro
AU  - Hisatsune C
FAU - Nagai, Terumi
AU  - Nagai T
FAU - Ebisui, Etsuko
AU  - Ebisui E
FAU - Mikoshiba, Katsuhiko
AU  - Mikoshiba K
FAU - Hirase, Hajime
AU  - Hirase H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Aniline Compounds)
RN  - 0 (Cholinergic Agents)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Fluoresceins)
RN  - 0 (Inositol 1,4,5-Trisphosphate Receptors)
RN  - 0 (Muscarinic Antagonists)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Oregon green 488 BAPTA-1)
RN  - 0 (Piperazines)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (S100 Proteins)
RN  - 0 (SR1001)
RN  - 0 (Sulfonamides)
RN  - 0 (Thiazoles)
RN  - 452VLY9402 (Serine)
RN  - 7C0697DR9I (Atropine)
RN  - 98Y1I8ZD4M (3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
EIN - J Neurosci. 2012 Aug 29;32(35):12303
MH  - Acetylcholine/pharmacology
MH  - Action Potentials/drug effects/genetics
MH  - Afferent Pathways/physiology
MH  - Aniline Compounds/metabolism
MH  - Animals
MH  - Astrocytes/drug effects/*physiology
MH  - Atropine/pharmacology
MH  - Basal Nucleus of Meynert/*physiology
MH  - Calcium Signaling/drug effects/genetics/*physiology
MH  - Cholinergic Agents/*metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Evoked Potentials, Somatosensory/drug effects/genetics
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Fluoresceins/metabolism
MH  - Inositol 1,4,5-Trisphosphate Receptors/deficiency
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Microdialysis/methods
MH  - Muscarinic Antagonists/pharmacology
MH  - Nerve Growth Factors/metabolism
MH  - Neuronal Plasticity/drug effects/genetics/*physiology
MH  - Neurons/drug effects/metabolism
MH  - Physical Stimulation
MH  - Piperazines/pharmacology
MH  - S100 Calcium Binding Protein beta Subunit
MH  - S100 Proteins/metabolism
MH  - Serine/pharmacology
MH  - Somatosensory Cortex/drug effects/*physiology
MH  - Sulfonamides/metabolism
MH  - Thiazoles/metabolism
MH  - Vibrissae/innervation
PMC - PMC6634158
EDAT- 2011/12/14 06:00
MHDA- 2012/02/03 06:00
PMCR- 2012/06/07
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
PHST- 2012/06/07 00:00 [pmc-release]
AID - 31/49/18155 [pii]
AID - 3743451 [pii]
AID - 10.1523/JNEUROSCI.5289-11.2011 [doi]
PST - ppublish
SO  - J Neurosci. 2011 Dec 7;31(49):18155-65. doi: 10.1523/JNEUROSCI.5289-11.2011.