PMID- 22159786
OWN - NLM
STAT- MEDLINE
DCOM- 20120605
LR  - 20240317
IS  - 1760-4788 (Electronic)
IS  - 1279-7707 (Linking)
VI  - 15
IP  - 10
DP  - 2011 Dec
TI  - Bone quantitative ultrasound measurements in relation to the metabolic syndrome 
      and type 2 diabetes mellitus in a cohort of elderly subjects at high risk of 
      cardiovascular disease from the PREDIMED study.
PG  - 939-44
AB  - OBJECTIVE: The aim of this study is to determine whether metabolic syndrome, its 
      individual components, or the presence of type 2 diabetes mellitus are associated 
      with a better bone status estimated by quantitative ultrasound at the calcaneus. 
      DESIGN: Cross-sectional study. SETTING: Outpatient clinics. PARTICIPANTS: 251 
      elderly subjects at high cardiovascular risk from the PREDIMED study were 
      included. MEASUREMENTS: MetS was defined according to the ATPIII diagnosis 
      criteria. Calcaneus quantitative ultrasound (QUS) assessment was performed using 
      the Sahara system. RESULTS: Subjects with MetS showed significantly lower 24-hour 
      urinary deoxypyridinoline/creatinine (u-DPD/creatinine) levels and higher 
      broadband ultrasound attenuation, and a tendency to higher bone mineral density 
      (BMD) and quantitative ultrasound index (QUI) than their counterparts. 
      Individuals with type 2 diabetes mellitus (T2DM) showed a significantly higher 
      bone broadband ultrasound attenuation (BUA) and QUI than their non-diabetic 
      counterparts, despite they shown a higher prevalence of osteoporotic fractures. 
      Multiple linear regression analyses showed that quantitative ultrasound 
      parameters were positively associated with the metabolic syndrome and T2DM. Of 
      the bone biochemical markers, only u-DPD/creatinine was related to MetS, 
      abdominal obesity, hypertriglyceridemia component of the MetS, and the number of 
      features that define the MetS. CONCLUSION: This is the first study showing a 
      positive association between MetS or T2DM with better bone status and lower bone 
      resorption markers measured by quantitative ultrasound. Our results suggest that 
      metabolic abnormalities have a positive effect on healthy bone in elderly 
      subjects at high risk of cardiovascular disease.
FAU - Bullo, M
AU  - Bullo M
AD  - Human Nutrition Unit, Facultat de Medicina i Ciencies de la Salut, IISPV, 
      Universitat Rovira i Virgili, Reus, Spain.
FAU - Garcia-Aloy, M
AU  - Garcia-Aloy M
FAU - Basora, J
AU  - Basora J
FAU - Covas, M I
AU  - Covas MI
FAU - Salas-Salvado, J
AU  - Salas-Salvado J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
RN  - 0 (Amino Acids)
RN  - 0 (Biomarkers)
RN  - 90032-33-0 (deoxypyridinoline)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Aged
MH  - Amino Acids/*urine
MH  - Biomarkers/urine
MH  - *Bone Density
MH  - Bone Resorption/*diagnostic imaging/urine
MH  - Bone and Bones/diagnostic imaging/*metabolism
MH  - Calcaneus/diagnostic imaging/metabolism
MH  - *Cardiovascular Diseases/diagnostic imaging
MH  - Creatinine/urine
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/diagnostic imaging/*metabolism/urine
MH  - Female
MH  - Fractures, Bone/epidemiology
MH  - Geriatric Assessment
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Metabolic Syndrome/diagnostic imaging/*metabolism/urine
MH  - Outpatients
MH  - Prevalence
MH  - Risk
MH  - Ultrasonography
EDAT- 2011/12/14 06:00
MHDA- 2012/06/06 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/06/06 06:00 [medline]
AID - S1279-7707(23)00583-3 [pii]
AID - 10.1007/s12603-011-0046-0 [doi]
PST - ppublish
SO  - J Nutr Health Aging. 2011 Dec;15(10):939-44. doi: 10.1007/s12603-011-0046-0.