PMID- 22160369
OWN - NLM
STAT- MEDLINE
DCOM- 20120620
LR  - 20211021
IS  - 1563-258X (Electronic)
IS  - 0043-5341 (Linking)
VI  - 161
IP  - 21-22
DP  - 2011 Nov
TI  - Training increases peroxiredoxin 2 contents in the erythrocytes of 
      overweight/obese men suffering from type 2 diabetes.
PG  - 511-8
LID - 10.1007/s10354-011-0037-0 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is associated with an increased release of free 
      radicals which play an important role in the manifestation of diabetes and in the 
      progression of diabetic complications. Peroxiredoxins are thought to be essential 
      components of the erythrocyte antioxidative defense. Therefore, we compared 
      peroxiredoxin isoform contents (PRDX1-6 immuno-histochemial stainings) in the 
      erythrocytes of overweight/obese T2DM men (n = 6) and of BMI-matched non-diabetic 
      male control subjects (n = 6). Only erythrocyte PRDX1 and PRDX2 proteins were 
      detectable using immunohistochemical methods. PRDX1 was significantly increased 
      in T2DM men relative to control subjects (+95.9%, P </= 0.05). Furthermore, we 
      studied the influence of a 3-month endurance training program (3 times a week, 
      cycling at 75% maximal heart rate) on erythrocyte PRDX1 and PRDX2 contents in 
      overweight/obese T2DM men (n = 11). Training significantly increased PRDX2 at 
      rest (+96%, P </= 0.05). The up-regulation of the peroxiredoxin system may help 
      counteract free radicals in the erythrocytes of T2DM patients.
FAU - Moghaddam, David Assadi
AU  - Moghaddam DA
AD  - Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular 
      Research and Sport Medicine, German Sport University Cologne, Cologne, Germany.
FAU - Heber, Anke
AU  - Heber A
FAU - Capin, Dario
AU  - Capin D
FAU - Kreutz, Thorsten
AU  - Kreutz T
FAU - Opitz, David
AU  - Opitz D
FAU - Lenzen, Edward
AU  - Lenzen E
FAU - Bloch, Wilhelm
AU  - Bloch W
FAU - Brixius, Klara
AU  - Brixius K
FAU - Brinkmann, Christian
AU  - Brinkmann C
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - Austria
TA  - Wien Med Wochenschr
JT  - Wiener medizinische Wochenschrift (1946)
JID - 8708475
RN  - 0 (Free Radicals)
RN  - EC 1.11.1.15 (PRDX2 protein, human)
RN  - EC 1.11.1.15 (Peroxiredoxins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*blood/*rehabilitation
MH  - Erythrocytes/*metabolism
MH  - Exercise/*physiology
MH  - Female
MH  - Free Radicals/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood/*rehabilitation
MH  - Overweight/*blood/*rehabilitation
MH  - Oxidative Stress/physiology
MH  - Peroxiredoxins/*blood
EDAT- 2011/12/14 06:00
MHDA- 2012/06/21 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/05/19 00:00 [received]
PHST- 2011/08/29 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/06/21 06:00 [medline]
AID - 10.1007/s10354-011-0037-0 [doi]
PST - ppublish
SO  - Wien Med Wochenschr. 2011 Nov;161(21-22):511-8. doi: 10.1007/s10354-011-0037-0.