PMID- 22160577
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20130530
IS  - 1573-9686 (Electronic)
IS  - 0090-6964 (Linking)
VI  - 40
IP  - 6
DP  - 2012 Jun
TI  - The current status of alternatives to animal testing and predictive toxicology 
      methods using liver microfluidic biochips.
PG  - 1228-43
LID - 10.1007/s10439-011-0480-5 [doi]
AB  - In this paper, we will consider new in vitro cell culture platforms and the 
      progress made, based on the microfluidic liver biochips dedicated to 
      pharmacological and toxicological studies. Particular emphasis will be given to 
      recent developments in the microfluidic tools dedicated to cell culture (more 
      particularly liver cell culture), in silico opportunities for Physiologically 
      Based PharmacoKinetic (PBPK) modelling, the challenge of the mechanistic 
      interpretations offered by the approaches resulting from "multi-omics" data 
      (transcriptomics, proteomics, metabolomics, cytomics) and imaging microfluidic 
      platforms. Finally, we will discuss the critical features regarding 
      microfabrication, design and materials, and cell functionality as the key points 
      for the future development of new microfluidic liver biochips.
FAU - Prot, Jean Matthieu
AU  - Prot JM
AD  - CNRS UMR 6600, Laboratoire de Biomecanique et Bioingenierie, Universite de 
      Technologie de Compiegne, Compiegne, France.
FAU - Leclerc, Eric
AU  - Leclerc E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111210
PL  - United States
TA  - Ann Biomed Eng
JT  - Annals of biomedical engineering
JID - 0361512
SB  - IM
MH  - 3T3 Cells
MH  - Animals
MH  - Dogs
MH  - Hep G2 Cells
MH  - Humans
MH  - *Liver
MH  - *Metabolomics/instrumentation/methods
MH  - Mice
MH  - *Microfluidic Analytical Techniques/instrumentation/methods
MH  - *Models, Biological
MH  - *Proteomics/instrumentation/methods
MH  - *Toxicology/instrumentation/methods
EDAT- 2011/12/14 06:00
MHDA- 2012/09/25 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/08/12 00:00 [received]
PHST- 2011/11/23 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
AID - 10.1007/s10439-011-0480-5 [doi]
PST - ppublish
SO  - Ann Biomed Eng. 2012 Jun;40(6):1228-43. doi: 10.1007/s10439-011-0480-5. Epub 2011 
      Dec 10.