PMID- 22161682
OWN - NLM
STAT- MEDLINE
DCOM- 20130213
LR  - 20211021
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Linking)
VI  - 17
IP  - 6
DP  - 2011 Dec
TI  - CD8+ T cells patrol HSV-1-infected trigeminal ganglia and prevent viral 
      reactivation.
PG  - 528-34
LID - 10.1007/s13365-011-0062-1 [doi]
AB  - A hallmark of herpes viruses is their capacity to cause recurrent disease. 
      Recurrences of herpes simplex virus (HSV)-1 disease do not result from 
      reinfection from external sources, but rather from reactivation of virus that is 
      maintained in a latent state in sensory neurons and periodically reactivates from 
      latency to cause recurrent disease. Recent findings implicate HSV-specific CD8(+) 
      T cells in immune surveillance of HSV-1 latently infected sensory neurons in 
      trigeminal ganglia (TG) and inhibition of HSV-1 reactivation from latency. This 
      review summarizes recent findings regarding the characteristics of the 
      TG-resident CD8(+) T cell population and certain unique obstacles that might 
      complicate the development of therapeutic vaccines.
FAU - St Leger, Anthony J
AU  - St Leger AJ
AD  - Graduate Program in Immunology, University of Pittsburgh School of Medicine, 
      Pittsburgh, PA 15213, USA.
FAU - Hendricks, Robert L
AU  - Hendricks RL
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111208
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (Antigens, Viral)
RN  - 0 (Cytokines)
RN  - 0 (Viral Proteins)
RN  - EC 3.4.21.- (Granzymes)
SB  - IM
MH  - Animals
MH  - Antigens, Viral/immunology
MH  - CD8-Positive T-Lymphocytes/*immunology/virology
MH  - Cytokines/immunology
MH  - Gene Expression Regulation, Viral/*immunology
MH  - Granzymes/immunology
MH  - Herpes Simplex/*immunology/virology
MH  - Herpesvirus 1, Human/*genetics/immunology
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Immunity, Innate
MH  - Mice
MH  - Mice, Knockout
MH  - Transcription, Genetic
MH  - Trigeminal Ganglion/*virology
MH  - Viral Proteins/genetics/*metabolism
MH  - Virus Latency/*physiology
EDAT- 2011/12/14 06:00
MHDA- 2013/02/14 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/09/15 00:00 [received]
PHST- 2011/11/13 00:00 [accepted]
PHST- 2011/10/11 00:00 [revised]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2013/02/14 06:00 [medline]
AID - 10.1007/s13365-011-0062-1 [doi]
PST - ppublish
SO  - J Neurovirol. 2011 Dec;17(6):528-34. doi: 10.1007/s13365-011-0062-1. Epub 2011 
      Dec 8.