PMID- 22162117
OWN - NLM
STAT- MEDLINE
DCOM- 20120628
LR  - 20151119
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 28
IP  - 3
DP  - 2012 Mar
TI  - Do patients with type 2 diabetes mellitus have an increased prevalence of 
      Cushing's syndrome?
PG  - 219-27
LID - 10.1002/dmrr.2262 [doi]
AB  - Many clinical features are common for patients with type 2 diabetes mellitus 
      (T2DM) and Cushing's syndrome (CS) such as central obesity, hypertension and 
      dyslipidaemia. Patients with CS often have T2DM. Because T2DM is much more 
      frequent than CS, it is possible that some patients with T2DM have increased 
      production of cortisol and thus represent patients with CS. The aim of this 
      review was to evaluate the prevalence of CS in patients with T2DM. A search was 
      performed in PubMed and Medline. We found seven prospective studies, two 
      case-control studies and two cross-sectional studies. The difficulties in 
      diagnosing subclinical CS is discussed. The most frequent tests for diagnosing 
      CS, late-night salivary cortisol, 1-mg dexamethasone suppression test and urinary 
      free cortisol are discussed and put in relation to the results of the literature 
      found. The observed prevalence of CS in patients with T2DM varies widely between 
      the different studies, ranging from 0-9.4%. This may be due to patient selection, 
      differences in test methodology (including choice of test), cutoff values and 
      different cortisol assays. The true prevalence of CS in T2DM has not been 
      determined. We need more studies investigating the prevalence of CS in T2DM 
      patients. There is a need for developing more specific tests for diagnosing CS in 
      patients with only slightly elevated cortisol secretion and subclinical CS. We 
      suggest that examination for hypercortisolism should only be performed in T2DM 
      patients with a cushingoid appearance and hypertension or truncal obesity or 
      dyslipidaemia.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Krarup, Therese
AU  - Krarup T
AD  - Department of Endocrinology and Internal Medicine, Bispebjerg Hospital, 
      Bispebjerg Bakke, Copenhagen 2400 NV, Denmark. theresekrarup@hotmail.com
FAU - Krarup, Thure
AU  - Krarup T
FAU - Hagen, Claus
AU  - Hagen C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Cushing Syndrome/diagnosis/*epidemiology
MH  - Dexamethasone
MH  - Diabetes Mellitus, Type 2/complications/*epidemiology
MH  - Humans
MH  - Hydrocortisone/urine
MH  - Hypertension/epidemiology
MH  - Prevalence
MH  - Prospective Studies
MH  - United States/epidemiology
EDAT- 2011/12/14 06:00
MHDA- 2012/06/29 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/06/29 06:00 [medline]
AID - 10.1002/dmrr.2262 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2012 Mar;28(3):219-27. doi: 10.1002/dmrr.2262.