PMID- 22162518
OWN - NLM
STAT- MEDLINE
DCOM- 20120702
LR  - 20220409
IS  - 2151-4658 (Electronic)
IS  - 2151-464X (Linking)
VI  - 64
IP  - 4
DP  - 2012 Apr
TI  - Pregnancy in women diagnosed with antineutrophil cytoplasmic antibody-associated 
      vasculitis: outcome for the mother and the child.
PG  - 539-45
LID - 10.1002/acr.21556 [doi]
AB  - OBJECTIVE: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is 
      infrequently seen in women of childbearing age. Only a limited number of 
      pregnancies in women with AAV have been reported, and often they were associated 
      with complications. METHODS: This was a single-center retrospective observational 
      study. All pregnancies in women with granulomatosis with polyangiitis (Wegener's) 
      (n = 13) and microscopic polyangiitis (n = 1) were included. Women of 
      childbearing age were counseled to abstain from pregnancy during or shortly after 
      disease activity or <1 year after cyclophosphamide treatment. RESULTS: We 
      described 22 pregnancies in 14 women with AAV (median age at diagnosis was 25 
      years [range 19-36 years]) diagnosed between 1982-2008. The ear, nose, and throat 
      region (71%) and kidneys (50%) were predominantly involved. All women were in 
      remission at conception and cyclophosphamide had been administered to 9 women (15 
      pregnancies). The median gestational age was 39+4 weeks, including 2 preterm 
      deliveries. The median birth weight was 3,400 gm (1,860-3,890 gm). Hypothyroidism 
      occurred in 1 newborn and a cleft palate in 1 newborn of a twin pregnancy. 
      Otherwise, the fetal outcome was excellent. Preeclampsia was diagnosed in 2 
      pregnancies. A caesarean section was performed in 2 patients. The median followup 
      after the last conception was 98 months (range 11-307 months). Eight women 
      experienced a relapse 21 months (range 7-62 months) after conception, 1 during 
      pregnancy, and 7 after delivery. CONCLUSION: In this study, the pregnancy outcome 
      in patients with AAV in remission was excellent. Pregnancy in women with AAV in 
      remission does not seem to be associated with increased risk of relapse. 
      Counseling, careful management, and close followup are essential in pregnant 
      women with AAV.
CI  - Copyright (c) 2012 by the American College of Rheumatology.
FAU - Tuin, J
AU  - Tuin J
AD  - University Medical Center Groningen, The Netherlands. j.tuin.1@student.rug.nl
FAU - Sanders, J S F
AU  - Sanders JS
FAU - de Joode, A A E
AU  - de Joode AA
FAU - Stegeman, C A
AU  - Stegeman CA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arthritis Care Res (Hoboken)
JT  - Arthritis care & research
JID - 101518086
RN  - 0 (Antirheumatic Agents)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Adult
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/*complications/*diagnosis/therapy
MH  - Antirheumatic Agents/therapeutic use
MH  - Cyclophosphamide/therapeutic use
MH  - Female
MH  - Humans
MH  - Hypothyroidism/epidemiology
MH  - Incidence
MH  - Pre-Eclampsia/epidemiology
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/*diagnosis/*therapy
MH  - *Pregnancy Outcome
MH  - Remission Induction
MH  - Retrospective Studies
MH  - Secondary Prevention
MH  - Treatment Outcome
EDAT- 2011/12/14 06:00
MHDA- 2012/07/03 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/07/03 06:00 [medline]
AID - 10.1002/acr.21556 [doi]
PST - ppublish
SO  - Arthritis Care Res (Hoboken). 2012 Apr;64(4):539-45. doi: 10.1002/acr.21556.