PMID- 22163260
OWN - NLM
STAT- MEDLINE
DCOM- 20120417
LR  - 20211021
IS  - 1866-0452 (Electronic)
IS  - 1866-0452 (Linking)
VI  - 108
IP  - 46
DP  - 2011 Nov
TI  - Intraductal papillary mucinous neoplasia (IPMN) of the pancreas: its diagnosis, 
      treatment, and prognosis.
PG  - 788-94
LID - 10.3238/arztebl.2011.0788 [doi]
AB  - BACKGROUND: The many varieties of cystic pancreatic tumor, and especially 
      intraductal papillary mucinous neoplasia (IPMN), have attracted increased 
      attention recently. Their incidence may be rising, and their histopathological 
      evaluation and classification have become more precise than before. METHODS: We 
      discuss the current diagnostic evaluation of IPMN, along with treatment and 
      prognostication, on the basis of the current international guideline as well as 
      pertinent literature retrieved by a selective PubMed search. RESULTS: The 
      preoperative diagnostic evaluation of IPMN is often problematic. In particular, 
      it may not be possible to differentiate main-duct disease from branch-duct 
      disease (MD-IPMN vs. BD-IPMN) before surgery--a distinction with implications for 
      prognosis and treatment, as MD-IPMN is more often malignant. An IPMN adenoma can 
      develop into invasive pancreatic cancer. Because firm diagnostic criteria are 
      still lacking, it is recommended that all MD-IPMN lesions and all large BD-IPMN 
      lesions should be resected. Partial pancreatectomy with clean margins is the 
      treatment of choice. CONCLUSION: As IPMN seems to be a slow-growing precursor of 
      pancreatic cancer, it is possible that its early detection and surgical treatment 
      can lead to a cure. No conclusion about the efficacy of surveillance and 
      follow-up programs can be drawn from the available evidence. A better 
      understanding of the natural course of IPMN and the biology of pancreatic cancer 
      is needed to enable further improvements in diagnosis and treatment.
FAU - Grutzmann, Robert
AU  - Grutzmann R
AD  - Chirurgische Klinik, Universitatsmedizin Mannheim, Med. Fakultat Mannheim, 
      Mannheim, Germany.
FAU - Post, Stefan
AU  - Post S
FAU - Saeger, Hans Detlev
AU  - Saeger HD
FAU - Niedergethmann, Marco
AU  - Niedergethmann M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111118
PL  - Germany
TA  - Dtsch Arztebl Int
JT  - Deutsches Arzteblatt international
JID - 101475967
SB  - IM
MH  - Adenocarcinoma, Mucinous/*diagnosis/*surgery
MH  - Humans
MH  - Pancreatectomy/*methods
MH  - Pancreatic Neoplasms/*diagnosis/*surgery
MH  - Papilloma, Intraductal/*diagnosis/*surgery
MH  - Prognosis
MH  - Treatment Outcome
PMC - PMC3230826
EDAT- 2011/12/14 06:00
MHDA- 2012/04/18 06:00
PMCR- 2011/11/01
CRDT- 2011/12/14 06:00
PHST- 2010/08/30 00:00 [received]
PHST- 2011/03/21 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/04/18 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - 10.3238/arztebl.2011.0788 [doi]
PST - ppublish
SO  - Dtsch Arztebl Int. 2011 Nov;108(46):788-94. doi: 10.3238/arztebl.2011.0788. Epub 
      2011 Nov 18.