PMID- 22165673
OWN - NLM
STAT- MEDLINE
DCOM- 20120104
LR  - 20220317
IS  - 1128-3602 (Print)
IS  - 1128-3602 (Linking)
VI  - 15
IP  - 10
DP  - 2011 Oct
TI  - Windows into estradiol effects in Alzheimer's disease therapy.
PG  - 1131-40
AB  - BACKGROUND AND OBJECTIVES: Alzheimer's disease (AD) is a neurological disorder 
      associated with aging. The neuropathologic features of this disease are senile 
      plaques and neurofibrillary tangles, which are present in memory structures and 
      cerebral cortex. This study focuses on evaluation of estradiol administration in 
      the management of neurological changes accompanied with AD in ovariectomized rats 
      intoxicated with aluminum. MATERIALS AND METHODS: Fifty adult female rats were 
      classified into 5 main groups as follows: Group (1): gonad intact control, Group 
      (2): ovariectomized control group, Group (3): ovariectomized rats were injected 
      subcutaneously with estradiol for 18 weeks, Group (4): ovariectomized rats were 
      injected intraperitoneally with aluminum chloride (AlCl3) daily for three months, 
      Group (5): ovariectomized rats were injected intraperitoneally with AlCl3 for 
      three months, then, they were injected subcutaneously with estradiol three times 
      weekly for 18 weeks. Hydrogen peroxide (H2O2), malondialdehyde (MDA), total 
      antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), B cell 
      lymphoma 2 (Bcl-2), brain derived neurotrophic factor (BDNF), 
      acetylcholinesterase (AchE) and acetylcholine (Ach) were determined in brain 
      tissue of all studied groups. RESULTS: The results showed that brain TAC, SOD 
      activity, Bcl-2 and BDNF levels were decreased significantly due to ovariectomy. 
      Brain H2O2, MDA levels and AchE activity were increased significantly after AlCl3 
      administration to ovariectomized rats. Brain TAC, Bcl-2, BDNF and Ach levels were 
      decreased significantly as a result of AlCl3 supplementation to ovariectomized 
      rats. Treatment of rats with estradiol produced marked improvement in the most 
      studied biomarkers and this finding was well documented by histological 
      investigation of the brain which showed remarkable improvement in the feature of 
      the neurons in addition to the disappearance of plaques. CONCLUSIONS: We could 
      conclude that estradiol administration significantly ameliorates the 
      neurodegeneration characteristic of Alzheimer's disease in experimental rat 
      model. This may be attributed to its powerful antioxidant, antiapoptotic, 
      neurotrophic as well as its antiamyloidogenic activities.
FAU - Mohamd, E M
AU  - Mohamd EM
AD  - Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.
FAU - Ahmed, H H
AU  - Ahmed HH
FAU - Estefan, S F
AU  - Estefan SF
FAU - Farrag, A E-R H
AU  - Farrag AE
FAU - Salah, R S
AU  - Salah RS
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Aluminum Compounds)
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Chlorides)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 3CYT62D3GA (Aluminum Chloride)
RN  - 4TI98Z838E (Estradiol)
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - Aluminum Chloride
MH  - Aluminum Compounds/toxicity
MH  - Alzheimer Disease/*drug therapy/metabolism
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Chlorides/toxicity
MH  - Estradiol/*therapeutic use
MH  - Female
MH  - Malondialdehyde/analysis
MH  - Proto-Oncogene Proteins c-bcl-2/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2011/12/15 06:00
MHDA- 2012/01/05 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/01/05 06:00 [medline]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2011 Oct;15(10):1131-40.