PMID- 22166457
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20221207
IS  - 1873-5126 (Electronic)
IS  - 1353-8020 (Linking)
VI  - 18 Suppl 1
DP  - 2012 Jan
TI  - Genetic variants in sporadic Parkinson's disease: East vs West.
PG  - S63-5
LID - 10.1016/S1353-8020(11)70021-9 [doi]
AB  - A number of gene variants or single nucleotide polymorphisms (SNPs) have been 
      shown to modulate the risk of Parkinson's disease (PD). These variants are 
      identified from genetic association studies of familial PD and candidate genes, 
      and from genome wide association studies (GWAS). These include REP1 dinucleotide 
      repeat polymorphism within the promoter region of the SNCA gene, and SNPs within 
      the vicinity of SNCA and LRRK2 genes. A number of exonic variants of LRRK2 
      (G2385R, R1628P, S1647T, M1646T, A419V, R1398H, N551K, Y2189C) have been shown to 
      influence PD risk in various ethnic populations. Numerous GWAS linked loci 
      including BST1 (bone marrow stromal cell antigen 1), PARK16 (parkinson disease 16 
      susceptibility), GAK (cyclin G associated kinase), and HLA (human leukocyte 
      antigen) have also been identified. The genetic variants have differential effect 
      on PD risk in Eastern and Western populations. Knowing the basis behind 
      ethnic-specific variances would further our understanding of the pathophysiologic 
      mechanisms and help planning of genetic testing programmes.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Peeraully, Tasneem
AU  - Peeraully T
AD  - Department of Neurology, Singapore General Hospital, Singapore.
FAU - Tan, E K
AU  - Tan EK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Parkinsonism Relat Disord
JT  - Parkinsonism & related disorders
JID - 9513583
SB  - IM
MH  - Asia/ethnology
MH  - Ethnicity/ethnology/*genetics
MH  - Genetic Variation/*genetics
MH  - *Genome-Wide Association Study
MH  - Humans
MH  - North America/ethnology
MH  - Parkinson Disease/diagnosis/ethnology/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - South America/ethnology
MH  - White People/ethnology/genetics
EDAT- 2011/12/23 06:00
MHDA- 2012/08/28 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - S1353-8020(11)70021-9 [pii]
AID - 10.1016/S1353-8020(11)70021-9 [doi]
PST - ppublish
SO  - Parkinsonism Relat Disord. 2012 Jan;18 Suppl 1:S63-5. doi: 
      10.1016/S1353-8020(11)70021-9.