PMID- 22166528
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20220318
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 123
IP  - 23
DP  - 2010 Dec
TI  - Association of neutrophil/lymphocyte ratio with long-term mortality after ST 
      elevation myocardial infarction treated with primary percutaneous coronary 
      intervention.
PG  - 3438-43
AB  - BACKGROUND: Primary percutaneous coronary interventions (PCI) have been proposed 
      as a novel superior management strategy in patients with ST elevation myocardial 
      infarction (STEMI). This study tested the hypothesis that in the acute phase of 
      myocardial infarction with ST-segment elevation, the neutrophil/lymphocyte (N/L) 
      ratio is a predictor of long-term prognosis. METHODS: We analyzed 551 consecutive 
      STEMI patients treated with primary PCI at a single university center. Patients 
      were stratified according to quartiles of the mean neutrophil/lymphocyte ratio. 
      RESULTS: Kaplan-Meier survival analysis showed a cumulative eight-year survival 
      of 94.2% in the first quartile, 92.0% in the second quartile, 91.3% in the third 
      quartile, and 75.4% in the fourth quartile (P < 0.001 by log rank). Relative to 
      patients in the other three lower N/L ratio quartiles, patients in the highest 
      quartile were more than four times more likely to die during hospitalization (P < 
      0.001) and during long-term follow-up (P < 0.001). By multivariate Cox regression 
      analysis including baseline demographic, clinical, and angiographic covariables, 
      the N/L ratio in the highest quartile remained an independent predictor of 
      mortality (hazard ratio 2.38, 95% confidence interval (CI) 1.42 to 3.98; P = 
      0.001). CONCLUSION: The neutrophil/lymphocyte ratio is a strong independent 
      predictor of long-term mortality after ST elevation myocardial infarction treated 
      with very early revascularization.
FAU - Shen, Xu-Hua
AU  - Shen XH
AD  - Department of Cardiology, Beijing Friendship Hospital Affiliated to Capital 
      Medical University, Beijing 100050, China.
FAU - Chen, Qi
AU  - Chen Q
FAU - Shi, Yan
AU  - Shi Y
FAU - Li, Hong-Wei
AU  - Li HW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Angioplasty, Balloon, Coronary
MH  - CD4 Lymphocyte Count
MH  - *Electrocardiography
MH  - Female
MH  - Humans
MH  - Lymphocytes/*physiology
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/immunology/*mortality/*therapy
MH  - Neutrophils/*physiology
MH  - Prognosis
MH  - Proportional Hazards Models
EDAT- 2011/12/15 06:00
MHDA- 2012/04/25 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2010 Dec;123(23):3438-43.