PMID- 22167486
OWN - NLM
STAT- MEDLINE
DCOM- 20130619
LR  - 20211021
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Linking)
VI  - 18
IP  - 1
DP  - 2012 Feb
TI  - Clonal expansions of CD8(+) T cells in latently HSV-1-infected human trigeminal 
      ganglia.
PG  - 62-8
LID - 10.1007/s13365-011-0067-9 [doi]
AB  - Herpes simplex virus type 1 latency in trigeminal ganglia (TG) is accompanied by 
      a chronic immune cell infiltration. The aim of this study was to analyse the 
      T-cell receptor beta-chain repertoire in latently HSV-1 infected human TG. Using 
      complementarity-determining region 3 spectratyping, 74 expanded beta-chain sequences 
      were identified in five TG. No clone appeared in more than one subject. Similar 
      clones were present in the right and the left TG of two subjects. This indicates 
      that these T cells are primed in the periphery and recognise the same antigen in 
      the TG of both sides.
FAU - Held, Kathrin
AU  - Held K
AD  - Institute of Clinical Neuroimmunology, Ludwig Maximilian University, 81377 
      Munich, Germany.
FAU - Eiglmeier, Ingrid
AU  - Eiglmeier I
FAU - Himmelein, Susanne
AU  - Himmelein S
FAU - Sinicina, Inga
AU  - Sinicina I
FAU - Brandt, Thomas
AU  - Brandt T
FAU - Theil, Diethilde
AU  - Theil D
FAU - Dornmair, Klaus
AU  - Dornmair K
FAU - Derfuss, Tobias
AU  - Derfuss T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111214
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (Complementarity Determining Regions)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Amino Acid Sequence
MH  - Autopsy
MH  - CD8-Positive T-Lymphocytes/immunology/*virology
MH  - Cell Movement/immunology
MH  - Cell Proliferation
MH  - Clone Cells/immunology/virology
MH  - Complementarity Determining Regions/genetics/immunology
MH  - Female
MH  - Herpes Simplex/immunology/*virology
MH  - Herpesvirus 1, Human/*physiology
MH  - Humans
MH  - Immunophenotyping
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Receptors, Antigen, T-Cell, alpha-beta/biosynthesis/immunology
MH  - Trigeminal Ganglion/immunology/*virology
MH  - Virus Latency/*immunology
EDAT- 2011/12/15 06:00
MHDA- 2013/06/20 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/10/07 00:00 [received]
PHST- 2011/11/28 00:00 [accepted]
PHST- 2011/11/23 00:00 [revised]
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2013/06/20 06:00 [medline]
AID - 10.1007/s13365-011-0067-9 [doi]
PST - ppublish
SO  - J Neurovirol. 2012 Feb;18(1):62-8. doi: 10.1007/s13365-011-0067-9. Epub 2011 Dec 
      14.