PMID- 22167487
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20161020
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 22
IP  - 5
DP  - 2012 Sep
TI  - Development of anti-neutrophil cytoplasmic antibody-associated vasculitis in a 
      patient with Graves' disease independent of anti-thyroid drug therapy.
PG  - 778-82
LID - 10.1007/s10165-011-0570-0 [doi]
AB  - Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) in patients with 
      Graves' disease (GD) is linked with the use of anti-thyroid drugs (ATDs). We 
      report the co-occurrence of AAV and GD in a patient that was independent of ATD 
      therapy. A 38-year-old white male presented with systemic symptoms, palpitations, 
      tremors, purpuric skin lesions, and digital pain. Physical examination and 
      biological tests confirmed GD. He quickly developed multiple digital gangrenes 
      and testicular pain/mass. Skin and testicular biopsies showed granulomatous 
      vasculitis of the small- and medium-sized vessels, while his serum contained 
      anti-proteinase-3 antibody.
FAU - Khan, Nasim Ahmed
AU  - Khan NA
AD  - Division of Rheumatology, University of Arkansas for Medical Sciences, 4301 West 
      Markham Street, #509, Little Rock, AR 72205, USA. nakhan@uams.edu
FAU - Singh, Manisha
AU  - Singh M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20111214
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Antithyroid Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Glucocorticoids)
RN  - 0 (Immunosuppressive Agents)
RN  - 721M9407IY (Propylthiouracil)
RN  - EC 3.4.21.76 (Myeloblastin)
RN  - MRK240IY2L (Azathioprine)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Adult
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/etiology/*pathology
MH  - Antibodies, Antineutrophil Cytoplasmic/immunology
MH  - Antithyroid Agents/adverse effects/*therapeutic use
MH  - Azathioprine/therapeutic use
MH  - Biomarkers
MH  - Drug Therapy, Combination
MH  - Glucocorticoids/therapeutic use
MH  - Graves Disease/complications/*drug therapy
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Male
MH  - Methylprednisolone/therapeutic use
MH  - Myeloblastin/immunology
MH  - Propylthiouracil/adverse effects/*therapeutic use
MH  - Remission Induction
MH  - Skin/blood supply/pathology
MH  - Testis/blood supply/pathology
MH  - Treatment Outcome
EDAT- 2011/12/15 06:00
MHDA- 2013/02/08 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/10/13 00:00 [received]
PHST- 2011/11/21 00:00 [accepted]
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
AID - 10.1007/s10165-011-0570-0 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2012 Sep;22(5):778-82. doi: 10.1007/s10165-011-0570-0. Epub 2011 
      Dec 14.