PMID- 22167758
OWN - NLM
STAT- MEDLINE
DCOM- 20120427
LR  - 20111214
IS  - 1522-6662 (Electronic)
IS  - 1098-3511 (Linking)
VI  - 14
IP  - 6
DP  - 2011 Dec
TI  - Elevated intraoperative expression of ventricular myosin light chain predicts 
      heart failure after valve replacement surgery.
PG  - E340-8
LID - 10.1532/HSF98.20111069 [doi]
AB  - BACKGROUND: It can be difficult to predict which patients will survive and 
      recover cardiac function after valve replacement surgery. We hypothesized that 
      the expression levels of ventricular myosin light chain (MLCv) might reflect the 
      severity of disease or the extent of irreversible myocardial damage and might be 
      useful for predicting the postoperative course. Thus, the aim of this study was 
      to explore the relationship between MLCv expression in specimens obtained during 
      valve replacement surgery and the postoperative New York Heart Association (NYHA) 
      class. METHODS: The levels of expression of the regulatory MLCv (MLC-2v) and 
      MLC-1v in papillary muscle specimens from 80 patients who underwent valve 
      replacement surgery for rheumatic valvular disease were evaluated by Western blot 
      analysis. RESULTS: The patients were similar with regard to the intraoperative 
      expression of MLC-1v, regardless of postoperative NYHA class. The preoperative 
      NYHA class, the end-systolic left ventricular internal dimension, and the 
      intraoperative expression of MLC-2v emerged as independent risks factors for a 
      NYHA class status of III/IV at 6 months after surgery, with an area under the 
      receiver operating characteristic curve of 0.862. CONCLUSION: The intraoperative 
      level of MLC-2v expression was predictive of the patients' NYHA class after valve 
      replacement surgery. This result suggests that future studies evaluating the use 
      of preoperative specimens (such as biopsy or peripheral blood samples) for 
      measurement of MLC-2v levels could lead to a valuable preoperative tool for the 
      assessment of candidates for valve replacement.
FAU - Feng, Qiang
AU  - Feng Q
AD  - Department of Cardiothoracic Surgery, The First Affiliated Hospital of Zhejiang 
      University Medical School, Hangzhou, People's Republic of China.
FAU - Zhang, Guo-Fei
AU  - Zhang GF
FAU - Ma, Liang
AU  - Ma L
FAU - Ni, Yi-Ming
AU  - Ni YM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Heart Surg Forum
JT  - The heart surgery forum
JID - 100891112
RN  - 0 (Myosin Light Chains)
SB  - IM
MH  - Blotting, Western
MH  - Female
MH  - Heart Failure/*metabolism
MH  - *Heart Valve Prosthesis Implantation
MH  - Humans
MH  - Intraoperative Care
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Myosin Light Chains/*metabolism
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - ROC Curve
MH  - Rheumatic Heart Disease/*metabolism/*surgery
MH  - Risk Factors
MH  - Statistics, Nonparametric
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2011/12/15 06:00
MHDA- 2012/04/28 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/04/28 06:00 [medline]
AID - L5117P0147464186 [pii]
AID - 10.1532/HSF98.20111069 [doi]
PST - ppublish
SO  - Heart Surg Forum. 2011 Dec;14(6):E340-8. doi: 10.1532/HSF98.20111069.