PMID- 22168
OWN - NLM
STAT- MEDLINE
DCOM- 19780127
LR  - 20191027
IS  - 0341-0382 (Print)
IS  - 0341-0382 (Linking)
VI  - 32
IP  - 9-10
DP  - 1977 Sep-Oct
TI  - On the mechanism of inactivation and ATP-dependent reactivation of rat liver 
      tyrosine aminotransferase.
PG  - 777-80
AB  - The mechanism of in vitro inactivation and ATP-dependent rapid reactivation of 
      rat liver tyrosine aminotransferase by a membrane-bound system from rat liver and 
      kidney cortex and the nucleotide specificity of this process was investigated 
      using partially purified tyrosine amino-transferase as a substrate. Adenosine 
      5'-triphosphate (ATP) could be replaced by guanosine 5'-triphosphate (GTP), 
      Whereas inosine 5'-triphosphate (ITP) was less effective. During reactivation 
      [gamma-32P]ATP was incorporated into the enzyme and not excorporated by 
      incubation of the labeled enzyme with excess non-radioative ATP. Inactivation of 
      labeled tyrosine aminotransferase by a particulate fraction led to a decrease 
      protein-bound radioactivity concomitant with an increase of [32P]orthophosphate. 
      This points to a phosphorylation and dephosphorylation mechanism in the 
      regulation of tyrosine aminotransferase activity.
FAU - Hamm, H H
AU  - Hamm HH
FAU - Seubert, W
AU  - Seubert W
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Z Naturforsch C Biosci
JT  - Zeitschrift fur Naturforschung. Section C, Biosciences
JID - 7801143
RN  - 5V5IOJ8338 (Pyridoxal Phosphate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 2.6.1.5 (Tyrosine Transaminase)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Adenosine Triphosphate/*pharmacology
MH  - Animals
MH  - Enzyme Activation/drug effects
MH  - Kinetics
MH  - Liver/*enzymology
MH  - Magnesium/pharmacology
MH  - Male
MH  - Pyridoxal Phosphate/pharmacology
MH  - Rats
MH  - Subcellular Fractions/enzymology
MH  - Tyrosine Transaminase/isolation & purification/*metabolism
EDAT- 1977/09/01 00:00
MHDA- 1977/09/01 00:01
CRDT- 1977/09/01 00:00
PHST- 1977/09/01 00:00 [pubmed]
PHST- 1977/09/01 00:01 [medline]
PHST- 1977/09/01 00:00 [entrez]
AID - 10.1515/znc-1977-9-1019 [doi]
PST - ppublish
SO  - Z Naturforsch C Biosci. 1977 Sep-Oct;32(9-10):777-80. doi: 
      10.1515/znc-1977-9-1019.