PMID- 22168638
OWN - NLM
STAT- MEDLINE
DCOM- 20120508
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 13
IP  - 1
DP  - 2011 Dec 14
TI  - Cardiovascular magnetic resonance tagging of the right ventricular free wall for 
      the assessment of long axis myocardial function in congenital heart disease.
PG  - 80
LID - 10.1186/1532-429X-13-80 [doi]
AB  - BACKGROUND: Right ventricular ejection fraction (RV-EF) has traditionally been 
      used to measure and compare RV function serially over time, but may be a 
      relatively insensitive marker of change in RV myocardial contractile function. We 
      developed a cardiovascular magnetic resonance (CMR) tagging-based technique with 
      a view to rapid and reproducible measurement of RV long axis function and applied 
      it in patients with congenital heart disease. METHODS: We studied 84 patients: 56 
      with repaired Tetralogy of Fallot (rTOF); 28 with atrial septal defect (ASD): 13 
      with and 15 without pulmonary hypertension (RV pressure > 40 mmHG by 
      echocardiography). For comparison, 20 healthy controls were studied. CMR 
      acquisitions included an anatomically defined four chamber cine followed by a 
      cine gradient echo-planar sequence in the same plane with a labelling pre-pulse 
      giving a tag line across the basal myocardium. RV tag displacement was measured 
      with automated registration and tracking of the tag line together with standard 
      measurement of RV-EF. RESULTS: Mean RV displacement was higher in the control (26 
      +/- 3 mm) than in rTOF (16 +/- 4 mm) and ASD with pulmonary hypertension (18 +/- 3 mm) 
      groups, but lower than in the ASD group without (30 +/- 4 mm), P < 0.001. The 
      technique was reproducible with inter-study bias +/- 95% limits of agreement of 0.7 
      +/- 2.7 mm. While RV-EF was lower in rTOF than in controls (49 +/- 9% versus 57 +/- 6%, 
      P < 0.001), it did not differ between either ASD group and controls. CONCLUSIONS: 
      Measurements of RV long axis displacement by CMR tagging showed more differences 
      between the groups studied than did RV-EF, and was reproducible, quick and easy 
      to apply. Further work is needed to assess its potential use for the detection of 
      longitudinal changes in RV myocardial function.
CI  - (c) 2011 Chen et al; licensee BioMed Central Ltd.
FAU - Chen, Sylvia S M
AU  - Chen SS
AD  - Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.
FAU - Keegan, Jennifer
AU  - Keegan J
FAU - Dowsey, Andrew W
AU  - Dowsey AW
FAU - Ismail, Tevfik
AU  - Ismail T
FAU - Wage, Ricardo
AU  - Wage R
FAU - Li, Wei
AU  - Li W
FAU - Yang, Guang-Zhong
AU  - Yang GZ
FAU - Firmin, David N
AU  - Firmin DN
FAU - Kilner, Philip J
AU  - Kilner PJ
LA  - eng
GR  - PG/08/122/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111214
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
SB  - IM
MH  - Adult
MH  - Cardiac Surgical Procedures
MH  - Case-Control Studies
MH  - Female
MH  - Heart Defects, Congenital/*diagnosis/pathology/physiopathology/surgery
MH  - Heart Ventricles/*pathology/*physiopathology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - London
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - *Stroke Volume
MH  - Ventricular Dysfunction, Right/*diagnosis/pathology/physiopathology
MH  - *Ventricular Function, Right
MH  - Young Adult
PMC - PMC3286381
EDAT- 2011/12/16 06:00
MHDA- 2012/05/09 06:00
PMCR- 2011/12/14
CRDT- 2011/12/16 06:00
PHST- 2011/05/02 00:00 [received]
PHST- 2011/12/14 00:00 [accepted]
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
PHST- 2011/12/14 00:00 [pmc-release]
AID - S1097-6647(23)01435-7 [pii]
AID - 1532-429X-13-80 [pii]
AID - 10.1186/1532-429X-13-80 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2011 Dec 14;13(1):80. doi: 10.1186/1532-429X-13-80.