PMID- 22169304
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20221207
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 19
IP  - 6
DP  - 2011 Dec
TI  - [Analysis of gene polymorphism of HPA and HLA-I in Chinese Xi'an voluntary 
      platelet donors].
PG  - 1462-5
AB  - To study the allele frequencies and their polymorphism characteristics of human 
      platelet antigen (HPA) and human leucocyte antigen-I (HLA-I) in Chinese xi'an 
      population, the types of HPA and HLA-I in 375 Chinese xi'an voluntary platelet 
      donors were detected by PCR-SSP and PCR-SSO as well as flow cytometry with 
      magnetic beads, and were analyzed. The results showed that there was no 
      polymorphism in HPA-7-HPA-14, HPA-16 and HPA-17 which only expressed-aa type, the 
      -bb type was only detected in HPA-3 and HPA-15, 9 out of 16 samples for the 
      HPA-5ab phenotype simultaneously expressed HPA-15ab, the other 7 samples 
      expressed HPA-15bb, no HPA-15aa phenotype was observed. Phenotypes detected in 
      this study were HPA-1aa-17aa, HPA-1ab, -2ab, -3ab, -3bb, -4ab, -5ab, -6ab, -15ab 
      and -15bb. Among 375 cases, HLA-A specificity of 16 species was observed, which 
      accounted for 76% (16/21) of detectable phenotype specificity in this locus, 
      moreover, 11 species showed frequency > 1%; HLA-B specificity of 36 species was 
      observed which accounted for 84% (36/43) of detectable phenotype specificity in 
      this locus, moreover 23 species showed frequency > 1%, these species were covered 
      by common specific HLA-I in northern China, 264 species haplotype HLA-A-B were 
      found in 375 cases, the frequency of 30 species was > 1%. It is concluded that 
      the gene frequency distribution of HPA and HLA-I in Chinese Xi'an population is 
      in accordance with population of northern China on the whole, but it has its own 
      characteristics.
FAU - Wang, Xiao-Fang
AU  - Wang XF
AD  - Blood Center of Shaanxi, Xi'an, Shaanxi Province, China. xinlvcheng2006@163.com
FAU - Liu, Meng-Li
AU  - Liu ML
FAU - Zhou, Dang-Xia
AU  - Zhou DX
FAU - Qi, Jun
AU  - Qi J
FAU - Liu, Sheng
AU  - Liu S
FAU - Wang, Tian-Ju
AU  - Wang TJ
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 0 (Antigens, Human Platelet)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Antigens, Human Platelet/*genetics
MH  - Asian People/genetics
MH  - *Blood Donors
MH  - China
MH  - Female
MH  - *Genes, MHC Class I
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Young Adult
EDAT- 2011/12/16 06:00
MHDA- 2012/12/10 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 1009-2137(2011)06-1462-04 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Dec;19(6):1462-5.