PMID- 22169381
OWN - NLM
STAT- MEDLINE
DCOM- 20120622
LR  - 20120228
IS  - 1473-0502 (Print)
IS  - 1473-0502 (Linking)
VI  - 46
IP  - 1
DP  - 2012 Feb
TI  - Hemolysis upon intravenous immunoglobulin transfusion.
PG  - 93-6
LID - 10.1016/j.transci.2011.11.004 [doi]
AB  - Intravenous immunoglobulin (IVIG) is a mainstay of therapy in many disorders. An 
      uncommon adverse side effect is IVIG-related hemolysis. Risk factors for 
      IVIG-related hemolysis have been identified, including high dose IVIG given to 
      non-O blood group recipients with an underlying inflammatory state. IVIG-related 
      hemolysis has been linked to anti-A and anti-B hemagglutinins in the IVIG 
      preparations and may involve both IgG and complement mediated hemolysis. A 
      two-hit mechanism with threshold effect is proposed for IVIG-related hemolysis. 
      Strategies exist to minimize or avoid IVIG-related hemolysis.
CI  - Copyright A(c) 2011 Elsevier Ltd. All rights reserved.
FAU - Padmore, Ruth F
AU  - Padmore RF
AD  - The Ottawa Hospital, General Campus, 501 Smyth Road, Ottawa, ON, Canada K1H 8L6. 
      rpadmore@ottawahospital.on.ca
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111213
PL  - England
TA  - Transfus Apher Sci
JT  - Transfusion and apheresis science : official journal of the World Apheresis 
      Association : official journal of the European Society for Haemapheresis
JID - 101095653
RN  - 0 (Hemagglutinins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
RN  - 9007-36-7 (Complement System Proteins)
MH  - Complement System Proteins/immunology/metabolism
MH  - Hemagglutinins/blood/immunology
MH  - Hemolysis/*drug effects
MH  - Humans
MH  - Immunoglobulin G/blood/immunology
MH  - Immunoglobulins, Intravenous/*adverse effects/therapeutic use
MH  - Immunologic Factors/*adverse effects/therapeutic use
MH  - Risk Factors
EDAT- 2011/12/16 06:00
MHDA- 2012/06/23 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/06/30 00:00 [received]
PHST- 2011/11/16 00:00 [accepted]
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/06/23 06:00 [medline]
AID - S1473-0502(11)00209-6 [pii]
AID - 10.1016/j.transci.2011.11.004 [doi]
PST - ppublish
SO  - Transfus Apher Sci. 2012 Feb;46(1):93-6. doi: 10.1016/j.transci.2011.11.004. Epub 
      2011 Dec 13.