PMID- 22169789
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20191112
IS  - 1972-2680 (Electronic)
IS  - 1972-2680 (Linking)
VI  - 5
IP  - 12
DP  - 2011 Dec 13
TI  - Are human herpes viruses associated with autoimmune thyroid disease?
PG  - 890-2
AB  - INTRODUCTION: Autoimmune diseases are complex diseases with genetic, endogenous 
      and environmental etiologies. Viral infections have been postulated as one of the 
      factors that may be the trigger of autoimmune diseases. METHODOLOGY: Thyroid 
      peroxidase (TPO) and thyroglobulin (TG) antibodies were measured before 
      thyroidectomy in 100 subjects by chemiluminescence method, 50 of whom were 
      autoimmune thyroid diseases (AITD) patients and 50 of whom were multinodular 
      goiter (MNG) patients used as a control group. Fresh thyroid samples were 
      collected from all 100 subjects after thyroidectomy to investigate the DNAs of 
      herpes simplex viruses types 1 and 2 (HSV-1, HSV-2), Varicella Zoster virus 
      (VZV), Epstein-Barr virus (EBV), Cytomegalovirus (CMV) and human herpes virus 
      type 6 (HHV-6) by PCR. RESULTS: The DNA of HSV-1, HSV-2, VZV, EBV, CMV and HHV-6 
      were detected in neither the patient group nor in the control group. The mean 
      values of anti-TPO and anti-TG antibodies ranged within 9.5-2000 units/ml (527.8 
      +/- 617.4) and 108-5000 units/ml (1458.2 +/- 1774.1) in the AITD patients group, 
      respectively. A statistically significant difference of the mean level of 
      anti-TPO and anti-TG antibodies among the two groups was found (p value < 0.05). 
      CONCLUSIONS: The possible role of human herpes viruses in the pathogenesis of 
      AITD is not supported by our study; hence our raised question stays open for more 
      investigation on more patients and in different parts of the country using 
      different sizes and sites of biopsies.
FAU - AL-Zarzour, Noura
AU  - AL-Zarzour N
AD  - Faculty of Pharmacy, Damascus University, Damascus, Syria. 
      noura_zarzour@hotmail.com
FAU - Monem, Fawza
AU  - Monem F
LA  - eng
PT  - Journal Article
DEP - 20111213
PL  - Italy
TA  - J Infect Dev Ctries
JT  - Journal of infection in developing countries
JID - 101305410
RN  - 0 (Autoantibodies)
RN  - 0 (DNA, Viral)
RN  - 9010-34-8 (Thyroglobulin)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
SB  - IM
MH  - Adult
MH  - Autoantibodies/*blood
MH  - DNA, Viral/genetics/*isolation & purification
MH  - Herpesviridae/*isolation & purification
MH  - Herpesviridae Infections/*complications
MH  - Humans
MH  - Iodide Peroxidase/immunology
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Thyroglobulin/immunology
MH  - Thyroid Gland/*virology
MH  - Thyroidectomy
MH  - Thyroiditis, Autoimmune/*pathology/*virology
EDAT- 2011/12/16 06:00
MHDA- 2012/04/05 06:00
CRDT- 2011/12/16 06:00
PHST- 2010/11/29 00:00 [received]
PHST- 2011/05/14 00:00 [accepted]
PHST- 2011/05/10 00:00 [revised]
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - 10.3855/jidc.1757 [doi]
PST - epublish
SO  - J Infect Dev Ctries. 2011 Dec 13;5(12):890-2. doi: 10.3855/jidc.1757.