PMID- 22170549
OWN - NLM
STAT- MEDLINE
DCOM- 20120606
LR  - 20111215
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 84
IP  - 2
DP  - 2012 Feb
TI  - Detection of herpes simplex virus (1 and 2), varicella-zoster virus, 
      cytomegalovirus, human herpesvirus 6 and enterovirus in immunocompetent Tunisian 
      patients with acute neuromeningeal disorder.
PG  - 282-9
LID - 10.1002/jmv.23192 [doi]
AB  - Enteroviruses (EVs) and human herpesviruses (HHVs) are involved frequently in 
      acute neurological disorders of viral etiology. This study aimed to investigate 
      the incidence of herpes simplex virus types-1 (HSV-1) and 2 (HSV-2), 
      varicella-zoster virus (VZV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) 
      and human enteroviruses (EVs) in cerebrospinal fluid (CSF) samples of Tunisian 
      immunocompetent patients with neuromeningeal disorders. The patients had been 
      hospitalized at the Fattouma Bourguiba University Hospital (Monastir, Tunisia) 
      between September 2007 and June 2009. At least one viral genome was detected in 
      58 (46%) out of 126 CSF samples collected. Enterovirus was detected in 31 of the 
      positive samples (53.4%), CMV in 20 (34.5%), HSV-1 in 3 (5.2%), HSV-2 in 6 
      (10.3%), VZV in 4 (6.9%), HHV-6 in 2 (3.4%). More than one viral genome was 
      detected in seven CSF samples, including CMV DNA in six of the samples. The high 
      frequency of enteroviral infections in aseptic meningitis was confirmed. The 
      detection of CMV DNA only suggests a direct role of this virus in the etiology of 
      acute neuromeningeal disorder.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Nahdi, Imen
AU  - Nahdi I
AD  - Laboratory of Contagious Diseases and Biologically Active Substances, LR99-ES27, 
      Faculty of Pharmacy, Monastir University, Monastir, Tunisia. amen_nahdi@yahoo.fr
FAU - Boukoum, Hanen
AU  - Boukoum H
FAU - Nabil Ben Salem, Abid
AU  - Nabil Ben Salem A
FAU - Ben Romdane, Fouad
AU  - Ben Romdane F
FAU - Hammami, Saber
AU  - Hammami S
FAU - Chebel, Saber
AU  - Chebel S
FAU - Mahbouba, Frih-Ayed
AU  - Mahbouba FA
FAU - Guediche, Mohamed Neji
AU  - Guediche MN
FAU - Chakroun, Mohamed
AU  - Chakroun M
FAU - Aouni, Mahjoub
AU  - Aouni M
FAU - Imbert-Marcille, Berthe-Marie
AU  - Imbert-Marcille BM
FAU - Bressollette-Bodin, Celine
AU  - Bressollette-Bodin C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (DNA, Viral)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - Cytomegalovirus/isolation & purification
MH  - DNA, Viral/cerebrospinal fluid
MH  - Enterovirus/immunology/*isolation & purification
MH  - Enterovirus Infections/*cerebrospinal fluid
MH  - Female
MH  - Herpesviridae/immunology/*isolation & purification
MH  - Herpesviridae Infections/*cerebrospinal fluid/epidemiology/virology
MH  - Herpesvirus 1, Human/isolation & purification
MH  - Herpesvirus 2, Human/isolation & purification
MH  - Herpesvirus 3, Human/isolation & purification
MH  - Herpesvirus 6, Human/isolation & purification
MH  - Humans
MH  - Infant
MH  - Male
MH  - Meninges/pathology/virology
MH  - Meningitis/*cerebrospinal fluid/pathology/virology
MH  - Middle Aged
MH  - RNA, Viral/cerebrospinal fluid
MH  - Tunisia/epidemiology
MH  - Young Adult
EDAT- 2011/12/16 06:00
MHDA- 2012/06/07 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/06/07 06:00 [medline]
AID - 10.1002/jmv.23192 [doi]
PST - ppublish
SO  - J Med Virol. 2012 Feb;84(2):282-9. doi: 10.1002/jmv.23192.