PMID- 22170554
OWN - NLM
STAT- MEDLINE
DCOM- 20120606
LR  - 20151119
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 84
IP  - 2
DP  - 2012 Feb
TI  - Possible implication of NFKB1A and NKG2D genes in susceptibility to 
      HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients 
      infected with HTLV-1.
PG  - 319-26
LID - 10.1002/jmv.22255 [doi]
AB  - The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of 
      HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a 
      progressive disease causing paraparesis of the lower limbs. Only a minority of 
      persons infected with HTLV-1 develop HAM/TSP. Universal susceptibility factors 
      for HAM/TSP are not known. The viral genotype is similar in asymptomatic carriers 
      and HAM/TSP patients. High proviral load has been associated consistently with 
      HAM/TSP, but this factor does not explain fully the presence of disease in 
      HTLV-1-infected subjects. Most likely, host genetic factors will play an 
      important role in HAM/TSP development. A two-stage case-control study was carried 
      out to evaluate the association between HAM/TSP and candidate single nucleotide 
      polymorphisms (SNPs) from 45 genes in addition to six human leukocyte antigen 
      (HLA) alleles. Ancestry-informative markers were used to correct for population 
      stratification. Several SNPs belonging to NFKB1A and NKG2D showed a trend of 
      association in both stages. The fact that the direction of the association 
      observed in the first stage was the same in the second stage suggests that NFKB1A 
      and NKG2D may be implicated in the development of HAM/TSP. Further replication 
      studies in independent HTLV-1 patient groups should validate further these 
      associations.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Talledo, Michael
AU  - Talledo M
AD  - Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana 
      Cayetano Heredia, Lima, Peru. michaeltalledo@yahoo.com
FAU - Lopez, Giovanni
AU  - Lopez G
FAU - Huyghe, Jeroen R
AU  - Huyghe JR
FAU - Verdonck, Kristien
AU  - Verdonck K
FAU - Gonzalez, Elsa
AU  - Gonzalez E
FAU - Clark, Daniel
AU  - Clark D
FAU - Vanham, Guido
AU  - Vanham G
FAU - Gotuzzo, Eduardo
AU  - Gotuzzo E
FAU - Van Camp, Guy
AU  - Van Camp G
FAU - Van Laer, Lut
AU  - Van Laer L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Biomarkers)
RN  - 0 (KLRK1 protein, human)
RN  - 0 (NF-kappa B p50 Subunit)
RN  - 0 (NFKB1 protein, human)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily K)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers
MH  - Case-Control Studies
MH  - Chromosome Mapping
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Human T-lymphotropic virus 1/immunology/*pathogenicity
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - NF-kappa B p50 Subunit/*genetics
MH  - NK Cell Lectin-Like Receptor Subfamily K/*genetics
MH  - Paraparesis, Tropical Spastic/*genetics/immunology/virology
MH  - Peru
MH  - Polymorphism, Single Nucleotide
MH  - Proviruses/immunology/pathogenicity
MH  - Spinal Cord Diseases/*genetics/immunology/virology
MH  - Viral Load
EDAT- 2011/12/16 06:00
MHDA- 2012/06/07 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/06/07 06:00 [medline]
AID - 10.1002/jmv.22255 [doi]
PST - ppublish
SO  - J Med Virol. 2012 Feb;84(2):319-26. doi: 10.1002/jmv.22255.