PMID- 22170817
OWN - NLM
STAT- MEDLINE
DCOM- 20121026
LR  - 20161125
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 26
IP  - 7
DP  - 2012 Jul
TI  - Ginsenoside Rg1 promotes glucose uptake through activated AMPK pathway in 
      insulin-resistant muscle cells.
PG  - 1017-22
LID - 10.1002/ptr.3686 [doi]
AB  - Ginsenoside Rg1, a protopanaxatriols saponin, is one of the major active 
      constituents from Panax ginseng and possesses various biological activities. A 
      recent study reported that insulin resistance in skeletal muscle is a major 
      contributor to the development of type 2 diabetes mellitus (T2DM). We examined 
      the effects of ginsenoside Rg1 on glucose uptake and the associated molecular 
      mechanisms of the glucose transport system in insulin-resistant muscle cells. The 
      insulin resistance of the muscle cell was induced by treatment of differentiated 
      C2C12 cells with chronic insulin. The results showed that chronic treatment of 
      insulin resulted in reduced glucose uptake in the muscle cells. The treatment of 
      ginsenoside Rg1 significantly enhanced glucose uptake in the differentiated 
      muscle cells and the relative abundance of GLUT4 through the 
      adenosine-monophosphate-activated protein kinase pathway. These results suggest 
      that ginsenoside Rg1 improved the insulin resistance in C2C12 muscle cells, which 
      might be useful for prevention of T2DM and metabolic syndromes.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Lee, Hye-Min
AU  - Lee HM
AD  - Graduate School of Biomedical Science, CHA University, Gyeonggi 463-836, Korea.
FAU - Lee, Ok-Hwan
AU  - Lee OH
FAU - Kim, Kui-Jin
AU  - Kim KJ
FAU - Lee, Boo-Yong
AU  - Lee BY
LA  - eng
PT  - Journal Article
DEP - 20111215
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Ginsenosides)
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Insulin)
RN  - 0 (Slc2a4 protein, mouse)
RN  - EC 2.7.4.3 (Adenylate Kinase)
RN  - IY9XDZ35W2 (Glucose)
RN  - PJ788634QY (ginsenoside Rg1)
SB  - IM
MH  - Adenylate Kinase/metabolism
MH  - Animals
MH  - Cell Line
MH  - Ginsenosides/*pharmacology
MH  - Glucose/*metabolism
MH  - Glucose Transporter Type 4/metabolism
MH  - Insulin/pharmacology
MH  - *Insulin Resistance
MH  - Mice
MH  - Muscle Cells/*metabolism
MH  - Panax/chemistry
MH  - Signal Transduction/*drug effects
EDAT- 2011/12/16 06:00
MHDA- 2012/10/27 06:00
CRDT- 2011/12/16 06:00
PHST- 2010/12/29 00:00 [received]
PHST- 2011/08/05 00:00 [revised]
PHST- 2011/09/22 00:00 [accepted]
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/10/27 06:00 [medline]
AID - 10.1002/ptr.3686 [doi]
PST - ppublish
SO  - Phytother Res. 2012 Jul;26(7):1017-22. doi: 10.1002/ptr.3686. Epub 2011 Dec 15.