PMID- 22172071
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20190823
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 18
IP  - 36
DP  - 2011
TI  - Evasion of host immunity by virulent Salmonella: implications for vaccine design.
PG  - 5666-75
AB  - Dendritic cells (DCs) are professional antigen presenting cells (APCs) capable of 
      linking innate and adaptive immunity during infection. After recognition of 
      pathogen-associated molecular patterns (PAMPs), DCs can engulf, process and 
      present bacteria-derived antigens on MHC molecules to T cells. Because of the key 
      role that DCs play on the initiation of innate and adaptive immunity, alterations 
      in their function could render the host susceptible to bacterial dissemination. 
      Consistent with this notion, is the observation that several pathogenic bacteria 
      have evolved mechanisms to impair the DC capacity to prime naive T cells. One of 
      such bacteria is Salmonella enterica serovar Typhimurium, which causes a 
      typhoid-like disease in mice and gastroenteritis in humans. Recent studies have 
      shown that virulent Salmonella can use intestinal DCs to spread inside the host, 
      evading T cell priming. The avoidance of T cell recognition by Salmonella is in 
      large part achieved by the activity of gene products encoded on Salmonella 
      Pathogenicity Islands -1 and - 2. The understanding of some of the remarkable 
      molecular virulence mechanisms displayed by Salmonella has contributed to the 
      design of new vaccines capable of inducing protective immunity against this 
      pathogen in mouse models. Here we describe recent data underscoring the virulence 
      mechanisms used by Salmonella to exploit DC function and discuss strategies based 
      on this new knowledge aimed at the design of new efficient and safe vaccines 
      against this pathogen.
FAU - Riquelme, S A
AU  - Riquelme SA
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica 
      Molecular y Microbiologia, Pontificia Universidad Catolica de Chile, Santiago 
      8331010, Chile.
FAU - Wozniak, A
AU  - Wozniak A
FAU - Kalergis, A M
AU  - Kalergis AM
FAU - Bueno, S M
AU  - Bueno SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Salmonella Vaccines)
RN  - 0 (Virulence Factors)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/immunology
MH  - Humans
MH  - Immunity/genetics/immunology
MH  - Salmonella Infections/*immunology/microbiology
MH  - Salmonella Vaccines/chemistry/*immunology
MH  - Salmonella typhimurium/*immunology/pathogenicity
MH  - Virulence Factors/*immunology
EDAT- 2011/12/17 06:00
MHDA- 2012/06/27 06:00
CRDT- 2011/12/17 06:00
PHST- 2011/05/02 00:00 [received]
PHST- 2011/07/27 00:00 [revised]
PHST- 2011/07/28 00:00 [accepted]
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - BSP/CMC/E-Pub/2011/418 [pii]
AID - 10.2174/092986711798347333 [doi]
PST - ppublish
SO  - Curr Med Chem. 2011;18(36):5666-75. doi: 10.2174/092986711798347333.