PMID- 22172933
OWN - NLM
STAT- MEDLINE
DCOM- 20120504
LR  - 20120102
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 507
IP  - 1
DP  - 2012 Jan 17
TI  - Relationship between circulating IGF-1 levels and traumatic brain injury-induced 
      hippocampal damage and cognitive dysfunction in immature rats.
PG  - 84-9
LID - 10.1016/j.neulet.2011.11.059 [doi]
AB  - It is well known that traumatic brain injury (TBI) induces the cognitive 
      dysfunction resulting from hippocampal damage. In the present study, we aimed to 
      assess whether the circulating IGF-I levels are associated with cognition and 
      hippocampal damage in 7-day-old rat pups subjected to contusion injury. 
      Hippocampal damage was examined by cresyl violet staining and terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. 
      Spatial memory performance was assessed in the Morris water maze. Serum IGF-1 
      levels decreased in both early and late period of TBI. Decreased levels of serum 
      IGF-1 were correlated with hippocampal neuron loss and spatial memory deficits. 
      Circulating IGF-1 levels may be predictive of cognitive dysfunction resulted from 
      hippocampal damage following traumatic injury in developing brain. Therapy 
      strategies that increase circulating IGF-1 may be highly promising for preventing 
      the unfavorable outcomes of traumatic damage in young children.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Ozdemir, Durgul
AU  - Ozdemir D
AD  - Dokuz Eylul University, Medical Faculty, Department of Pediatrics, Izmir, Turkey. 
      durgul.ozdemir@deu.edu.tr
FAU - Baykara, Basak
AU  - Baykara B
FAU - Aksu, Ilkay
AU  - Aksu I
FAU - Kiray, Muge
AU  - Kiray M
FAU - Sisman, Ali Riza
AU  - Sisman AR
FAU - Cetin, Ferihan
AU  - Cetin F
FAU - Dayi, Ayfer
AU  - Dayi A
FAU - Gurpinar, Tugba
AU  - Gurpinar T
FAU - Uysal, Nazan
AU  - Uysal N
FAU - Arda, M Nuri
AU  - Arda MN
LA  - eng
PT  - Journal Article
DEP - 20111208
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Brain Injuries/*blood/*complications
MH  - *Cognition
MH  - Cognition Disorders/*blood/complications
MH  - Hippocampus/*injuries/*metabolism/pathology
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Statistics as Topic
EDAT- 2011/12/17 06:00
MHDA- 2012/05/05 06:00
CRDT- 2011/12/17 06:00
PHST- 2011/09/27 00:00 [received]
PHST- 2011/11/04 00:00 [revised]
PHST- 2011/11/28 00:00 [accepted]
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2012/05/05 06:00 [medline]
AID - S0304-3940(11)01581-3 [pii]
AID - 10.1016/j.neulet.2011.11.059 [doi]
PST - ppublish
SO  - Neurosci Lett. 2012 Jan 17;507(1):84-9. doi: 10.1016/j.neulet.2011.11.059. Epub 
      2011 Dec 8.