PMID- 2217309
OWN - NLM
STAT- MEDLINE
DCOM- 19901121
LR  - 20051117
IS  - 0361-7742 (Print)
IS  - 0361-7742 (Linking)
VI  - 341B
DP  - 1990
TI  - Effect of chronic caloric restriction on hepatic enzymes of intermediary 
      metabolism in aged B6C3F1 female mice.
PG  - 177-85
AB  - Caloric restriction (CR) extends maximum life span and significantly retards the 
      rate of occurrence of most age-associated degenerative diseases. The effect of CR 
      in female mice on several hepatic enzymes was examined after 33 month old mice 
      were killed at either the onset of dark, the onset of light or the mid-dark span. 
      Animals had been singly caged with 12 hr of light followed by 12 hr of dark. All 
      feeding was in the early dark span. CR mice were given 60% of the caloric intake 
      of ad libitum fed mice throughout their lives (CR was initiated at 14 weeks of 
      age). Livers were frozen to await preparation and then analysis for 14 enzymes of 
      intermediary metabolism by our standard procedures. Enzymes of gluconeogenesis 
      and amino acid metabolism were increased at all times due to CR. Enzymes of 
      glycolysis and lipid metabolism were decreased at all times. However, maximum 
      differences between ad libitum and CR mice occurred during the mid-dark span 
      (this is the time of normal acrophase in younger mice). Circadian variation was 
      lost and mesors changed for nearly all enzymes measured from mice that had been 
      fed ad libitum. CR mice were found to maintain circadian variation of activities 
      and activity profiles were similar to those seen in younger ad libitum fed mice. 
      These observations suggest that the mechanism through which CR elicits its 
      effects may involve a circadian component.
FAU - Feuers, R J
AU  - Feuers RJ
AD  - National Center for Toxicological, Research, Jefferson, AR.
FAU - Leakey, J E
AU  - Leakey JE
FAU - Duffy, P H
AU  - Duffy PH
FAU - Hart, R W
AU  - Hart RW
FAU - Scheving, L E
AU  - Scheving LE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prog Clin Biol Res
JT  - Progress in clinical and biological research
JID - 7605701
SB  - IM
MH  - Aging/metabolism
MH  - Animals
MH  - Circadian Rhythm/physiology
MH  - Fasting/*metabolism
MH  - Female
MH  - Gluconeogenesis/physiology
MH  - Glycolysis/physiology
MH  - Lipid Metabolism
MH  - Liver/*enzymology
MH  - Longevity/physiology
MH  - Mice
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
PST - ppublish
SO  - Prog Clin Biol Res. 1990;341B:177-85.