PMID- 22173879
OWN - NLM
STAT- MEDLINE
DCOM- 20120709
LR  - 20211021
IS  - 1573-2592 (Electronic)
IS  - 0271-9142 (Linking)
VI  - 32
IP  - 2
DP  - 2012 Apr
TI  - Immune reconstitution following unmanipulated HLA-mismatched/haploidentical 
      transplantation compared with HLA-identical sibling transplantation.
PG  - 268-80
LID - 10.1007/s10875-011-9630-7 [doi]
AB  - In this study, we prospectively investigated the immune reconstitution in 
      patients with hematological malignancies after human leukocyte antigen 
      (HLA)-mismatched/unmanipulated haploidentical transplantation (50 cases) and 
      HLA-matched transplant (25 cases). Transplant-related mortality, relapse, 
      leukemia-free survival, and overall survival were similar between the two 
      transplant strategies, although the cumulative incidence of CMV antigenemia was 
      significantly higher in haploidentical recipients than in HLA-matched recipients 
      (49.9 +/- 7.2% versus 13 +/- 7%, P = 0.007). Compared with HLA-matched recipients, 
      T-cell subset and dendritic cell subgroup cell counts in the first 90 days after 
      grafting were lower in haploidentical recipients. The difference was most 
      striking for CD4(+) and CD4(+) naive T cells. Reconstitution of B cells and 
      monocytes was comparable between groups. T cells appeared equally functional in 
      both groups among patients without graft-versus-host disease. Our results suggest 
      that the clinical outcomes were not compromised by the early delayed immune 
      reconstitution following haploidentical transplantation.
FAU - Chang, Ying-Jun
AU  - Chang YJ
AD  - Peking University People's Hospital & Institute of Hematology, Beijing 100044, 
      China.
FAU - Zhao, Xiang-Yu
AU  - Zhao XY
FAU - Huo, Ming-Rui
AU  - Huo MR
FAU - Xu, Lan-Ping
AU  - Xu LP
FAU - Liu, Dai-Hong
AU  - Liu DH
FAU - Liu, Kai-Yan
AU  - Liu KY
FAU - Huang, Xiao-Jun
AU  - Huang XJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111216
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - B-Lymphocytes/immunology/metabolism
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/immunology/metabolism
MH  - Female
MH  - Graft vs Host Disease/etiology/immunology
MH  - HLA Antigens/*immunology
MH  - Hematologic Neoplasms/*immunology/mortality/*therapy
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Histocompatibility/*immunology
MH  - Humans
MH  - Infections/complications
MH  - Male
MH  - Middle Aged
MH  - Siblings
MH  - T-Lymphocyte Subsets/immunology/metabolism
MH  - Time Factors
MH  - Transplantation, Homologous
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/12/17 06:00
MHDA- 2012/07/10 06:00
CRDT- 2011/12/17 06:00
PHST- 2011/08/15 00:00 [received]
PHST- 2011/12/02 00:00 [accepted]
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2012/07/10 06:00 [medline]
AID - 10.1007/s10875-011-9630-7 [doi]
PST - ppublish
SO  - J Clin Immunol. 2012 Apr;32(2):268-80. doi: 10.1007/s10875-011-9630-7. Epub 2011 
      Dec 16.