PMID- 22174491
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20240323
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2011
DP  - 2011
TI  - Differential effects of acute (extenuating) and chronic (training) exercise on 
      inflammation and oxidative stress status in an animal model of type 2 diabetes 
      mellitus.
PG  - 253061
LID - 10.1155/2011/253061 [doi]
LID - 253061
AB  - This study compares the effects of a single bout of exercise (acute extenuating) 
      with those promoted by an exercise training program (chronic), focusing on 
      low-grade chronic inflammation profile and on oxidative stress status, using the 
      obese ZDF rats as a model of type 2 diabetes mellitus (T2DM). Animals were 
      sacrificed after 12 weeks of a swimming training program and after a single bout 
      of acute extenuating exercise. Glycaemic, insulinemic, and lipidic profile 
      (triglycerides, total-cholesterol) were evaluated, as well as inflammatory (serum 
      CRPhs, TNF-alpha, adiponectin) and oxidative (lipidic peroxidation and uric acid) 
      status. When compared to obese diabetic sedentary rats, the animals submitted to 
      acute exercise presented significantly lower values of glycaemia and 
      insulinaemia, with inflammatory profile and oxidative stress significantly 
      aggravated. The trained animals showed amelioration of glycaemic and lipidic 
      dysmetabolism, accompanied by remarkable reduction of inflammatory and oxidative 
      markers. In conclusion, the results presented herein suggessted that exercise 
      pathogenesis-oriented interventions should not exacerbate underlying inflammatory 
      stress associated with T2DM.
FAU - Teixeira de Lemos, Edite
AU  - Teixeira de Lemos E
AD  - Laboratory of Pharmacology & Experimental Therapeutics, Institute for Biomedical 
      Research on Light and Image, Coimbra University, 3000-548 Coimbra, Portugal.
FAU - Pinto, Rui
AU  - Pinto R
FAU - Oliveira, Jorge
AU  - Oliveira J
FAU - Garrido, Patricia
AU  - Garrido P
FAU - Sereno, Jose
AU  - Sereno J
FAU - Mascarenhas-Melo, Filipa
AU  - Mascarenhas-Melo F
FAU - Pascoa-Pinheiro, Joao
AU  - Pascoa-Pinheiro J
FAU - Teixeira, Frederico
AU  - Teixeira F
FAU - Reis, Flavio
AU  - Reis F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111115
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Lipids)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Disease Models, Animal
MH  - Exercise/*physiology
MH  - Humans
MH  - Inflammation/blood/*physiopathology
MH  - Lipids/blood
MH  - Male
MH  - *Oxidative Stress
MH  - Random Allocation
MH  - Rats
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Uric Acid/blood
PMC - PMC3235883
EDAT- 2011/12/17 06:00
MHDA- 2012/04/17 06:00
PMCR- 2011/11/15
CRDT- 2011/12/17 06:00
PHST- 2011/07/18 00:00 [received]
PHST- 2011/08/20 00:00 [accepted]
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
PHST- 2011/11/15 00:00 [pmc-release]
AID - 10.1155/2011/253061 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2011;2011:253061. doi: 10.1155/2011/253061. Epub 2011 Nov 15.