PMID- 22174637
OWN - NLM
STAT- MEDLINE
DCOM- 20141230
LR  - 20220606
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 12
IP  - 11
DP  - 2011
TI  - Rapid and green analytical method for the determination of quinoline alkaloids 
      from Cinchona succirubra based on Microwave-Integrated Extraction and Leaching 
      (MIEL) prior to high performance liquid chromatography.
PG  - 7846-60
LID - 10.3390/ijms12117846 [doi]
AB  - Quinas contains several compounds, such as quinoline alkaloids, principally 
      quinine, quinidine, cinchonine and cichonidine. Identified from barks of 
      Cinchona, quinine is still commonly used to treat human malaria. 
      Microwave-Integrated Extraction and Leaching (MIEL) is proposed for the 
      extraction of quinoline alkaloids from bark of Cinchona succirubra. The process 
      is performed in four steps, which ensures complete, rapid and accurate extraction 
      of the samples. Optimal conditions for extraction were obtained using a response 
      surface methodology reached from a central composite design. The MIEL extraction 
      has been compared with a conventional technique soxhlet extraction. The extracts 
      of quinoline alkaloids from C. succirubra obtained by these two different methods 
      were compared by HPLC. The extracts obtained by MIEL in 32 min were 
      quantitatively (yield) and qualitatively (quinine, quinidine, cinchonine, 
      cinchonidine) similar to those obtained by conventional Soxhlet extraction in 3 
      hours. MIEL is a green technology that serves as a good alternative for the 
      extraction of Cinchona alkaloids.
FAU - Fabiano-Tixier, Anne-Sylvie
AU  - Fabiano-Tixier AS
AD  - UMR 408 INRA, Safety and Quality of Plant Products, University of Avignon, 84000 
      Avignon, France; E-Mails: emmanuel.petitcolas@univ-avignon.fr (E.P.); 
      farid.chemat@univ-avignon.fr (F.C.).
FAU - Elomri, Abdelhakim
AU  - Elomri A
FAU - Blanckaert, Axelle
AU  - Blanckaert A
FAU - Seguin, Elisabeth
AU  - Seguin E
FAU - Petitcolas, Emmanuel
AU  - Petitcolas E
FAU - Chemat, Farid
AU  - Chemat F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111114
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Antimalarials)
RN  - 0 (Cinchona Alkaloids)
RN  - 0 (Plant Extracts)
RN  - 0 (Quinolines)
RN  - 1U622LRA8Z (cinchonidine)
RN  - A7V27PHC7A (Quinine)
RN  - E66400VT9R (quinoline)
RN  - ITX08688JL (Quinidine)
RN  - V43X79NZCD (cinchonine)
SB  - IM
MH  - Antimalarials/analysis
MH  - Chromatography, High Pressure Liquid
MH  - Cinchona/*chemistry
MH  - Cinchona Alkaloids/analysis
MH  - Green Chemistry Technology
MH  - Microwaves
MH  - Plant Bark/chemistry
MH  - Plant Extracts/*analysis
MH  - Quinidine/analysis
MH  - Quinine/analysis
MH  - Quinolines/*analysis
PMC - PMC3233443
OTO - NOTNLM
OT  - Cinchona alkaloids
OT  - HPLC
OT  - Soxhlet
OT  - extraction
OT  - microwave
EDAT- 2011/12/17 06:00
MHDA- 2011/12/17 06:01
PMCR- 2011/01/01
CRDT- 2011/12/17 06:00
PHST- 2011/09/09 00:00 [received]
PHST- 2011/10/21 00:00 [revised]
PHST- 2011/10/31 00:00 [accepted]
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2011/12/17 06:01 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - ijms12117846 [pii]
AID - ijms-12-07846 [pii]
AID - 10.3390/ijms12117846 [doi]
PST - ppublish
SO  - Int J Mol Sci. 2011;12(11):7846-60. doi: 10.3390/ijms12117846. Epub 2011 Nov 14.