PMID- 22176219
OWN - NLM
STAT- MEDLINE
DCOM- 20121206
LR  - 20200319
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 122
IP  - 5
DP  - 2012 May
TI  - Neurotrophic effects of magnesium fructose 1, 6-diphosphate on cortical neurons.
PG  - 248-54
LID - 10.3109/00207454.2011.648291 [doi]
AB  - In this study, we evaluated the neurotrophic effects of magnesium fructose 1, 
      6-diphosphate (FDP-Mg) on cortical neurons. The results demonstrated that FDP-Mg 
      promoted dendrite outgrowth and neuronal survival in a dose-dependent manner. In 
      order to investigate the associated mechanisms, we determined adenosine 
      triphosphate (ATP) levels and brain-derived neurotrophic factor (BDNF) mRNA 
      expression in cortical neurons. Treatment with FDP-Mg significantly increased ATP 
      levels and BDNF mRNA expression in cortical neurons. These data suggest that 
      FDP-Mg can exert neurotrophic effects on cortical neurons. The increases in BDNF 
      mRNA expression and cellular ATP levels are involved in the neurotrophic effects 
      produced by FDP-Mg.
FAU - Lin, Lian-Feng
AU  - Lin LF
AD  - Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 
      510632 China.
FAU - Xue, Xiao-Yan
AU  - Xue XY
FAU - Liao, Min-Jing
AU  - Liao MJ
FAU - Xiao, Fei
AU  - Xiao F
FAU - Lv, Ruo-Hua
AU  - Lv RH
FAU - Luo, Huan-Min
AU  - Luo HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120120
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
RN  - 0 (Fructosediphosphates)
RN  - 0 (MAP2 protein, rat)
RN  - 0 (Microtubule-Associated Proteins)
RN  - I38ZP9992A (Magnesium)
RN  - M7522JYX1H (fructose-1,6-diphosphate)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Cell Survival/drug effects
MH  - Cerebral Cortex/*cytology
MH  - Dendrites/*drug effects/physiology
MH  - Fructosediphosphates/*pharmacology
MH  - Magnesium/*pharmacology
MH  - Microtubule-Associated Proteins/metabolism
MH  - Neurogenesis/drug effects/physiology
MH  - Neurons/cytology/*drug effects/physiology
MH  - Rats
EDAT- 2011/12/20 06:00
MHDA- 2012/12/10 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.3109/00207454.2011.648291 [doi]
PST - ppublish
SO  - Int J Neurosci. 2012 May;122(5):248-54. doi: 10.3109/00207454.2011.648291. Epub 
      2012 Jan 20.