PMID- 22178160
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20120110
IS  - 1879-291X (Electronic)
IS  - 0301-5629 (Linking)
VI  - 38
IP  - 2
DP  - 2012 Feb
TI  - Ultrasound enhanced prehospital thrombolysis using microbubbles infusion in 
      patients with acute ST elevation myocardial infarction: pilot of the Sonolysis 
      study.
PG  - 247-52
LID - 10.1016/j.ultrasmedbio.2011.11.001 [doi]
AB  - In animal studies, transthoracic ultrasound and microbubbles have shown to 
      dissolve thrombi in ST elevation myocardial infarction (STEMI). To examine this 
      effect in patients, we have initiated the Sonolysis trial. In this pilot study of 
      10 patients with a first acute STEMI, we investigated the safety and feasibility 
      of this trial. After pretreatment in the ambulance, five patients were randomized 
      to receive microbubbles with three-dimensional (3-D) guided high mechanical index 
      impulses (1.18) for 15 min, whereas the control group received placebo without 
      ultrasound. Subsequently, primary percutaneous coronary intervention (PPCI) was 
      performed, if indicated. All patients successfully underwent study treatment and 
      PPCI. No significant difference between treatment and control group in safety 
      (minor adverse events 2/5 vs. 2/5, p = NS) and outcome (TIMI III flow 3/5 vs. 1/5 
      respectively, p = 0.23) was recorded. These results demonstrate that the study 
      protocol is feasible in the acute cardiac care setting and safe during treatment 
      and follow-up.
CI  - Copyright (c) 2012 World Federation for Ultrasound in Medicine & Biology. Published 
      by Elsevier Inc. All rights reserved.
FAU - Slikkerveer, Jeroen
AU  - Slikkerveer J
AD  - Department of Cardiology, VU University Medical Center, Amsterdam, The 
      Netherlands. j.slikkerveer@vumc.nl
FAU - Kleijn, Sebastiaan A
AU  - Kleijn SA
FAU - Appelman, Yolande
AU  - Appelman Y
FAU - Porter, Thomas R
AU  - Porter TR
FAU - Veen, Gerrit
AU  - Veen G
FAU - van Rossum, Albert C
AU  - van Rossum AC
FAU - Kamp, Otto
AU  - Kamp O
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111216
PL  - England
TA  - Ultrasound Med Biol
JT  - Ultrasound in medicine & biology
JID - 0410553
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Emergency Medical Services/*methods
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Infusions, Parenteral
MH  - Male
MH  - Microbubbles/*therapeutic use
MH  - Middle Aged
MH  - Myocardial Infarction/*therapy
MH  - Pilot Projects
MH  - Thrombolytic Therapy/*methods
MH  - Treatment Outcome
MH  - Ultrasonic Therapy/*methods
MH  - Young Adult
EDAT- 2011/12/20 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/08/05 00:00 [received]
PHST- 2011/10/27 00:00 [revised]
PHST- 2011/11/05 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - S0301-5629(11)01478-5 [pii]
AID - 10.1016/j.ultrasmedbio.2011.11.001 [doi]
PST - ppublish
SO  - Ultrasound Med Biol. 2012 Feb;38(2):247-52. doi: 
      10.1016/j.ultrasmedbio.2011.11.001. Epub 2011 Dec 16.