PMID- 22178241
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20181201
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 136
IP  - 3
DP  - 2012 Feb
TI  - Underestimating the severity of bipolar depression: a comparison of the Hamilton 
      Depression Rating Scale items.
PG  - 425-9
LID - 10.1016/j.jad.2011.11.007 [doi]
AB  - BACKGROUND: The Hamilton Depression Rating Scale (HDRS) is a clinician-rated 
      instrument to assess the severity of depressive symptoms that does not account 
      for the differences between bipolar (BP) and unipolar (UP) disorders. This study 
      attempts to evaluate differences in the total scores of the HDRS, Beck Depression 
      Inventory (BDI), and Global Assessment of Functioning (GAF) ratings of patients 
      with bipolar II (BP-II) and UP depression. Each factor and item of the HDRS was 
      compared between the two groups in order to identify specific symptoms. METHODS: 
      588 patients with bipolar II disorder (n=101) and major depressive disorder 
      (n=487) were enrolled in this study. All participants completed the BDI and 
      individually interviewed using HDRS. Each participant was also evaluated with 
      regard to global functioning. RESULTS: The BP group scored lower on the total 
      HDRS and all of the factors. The BP and UP groups did not differ in terms of BDI 
      and GAF. With regard to the individual items of HDRS, the BP group scored lower 
      on items associated with 'Depressed mood', 'Work and interest', 'Somatic, 
      gastro', and 'Hypochondriasis'. LIMITATIONS: There was a significant age 
      differences between the two groups. CONCLUSIONS: The results of this study 
      suggest that the severity of bipolar depression may be less well-recognized by 
      the HDRS due to the different presentations of depressive symptoms. Thus, the 
      clinician should be careful not to underestimate the sincerity of patients' 
      reports when evaluating depression.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Sung, Gyhye
AU  - Sung G
AD  - Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung 
      Medical Center, Seoul, South Korea.
FAU - Kim, Bin-Na
AU  - Kim BN
FAU - Lee, Eun-Ho
AU  - Lee EH
FAU - Yu, Bum-Hee
AU  - Yu BH
FAU - Hong, Kyung Sue
AU  - Hong KS
FAU - Kim, Ji-Hae
AU  - Kim JH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20111216
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bipolar Disorder/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Psychiatric Status Rating Scales
MH  - Severity of Illness Index
EDAT- 2011/12/20 06:00
MHDA- 2012/10/10 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/08/10 00:00 [received]
PHST- 2011/11/08 00:00 [revised]
PHST- 2011/11/08 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - S0165-0327(11)00720-8 [pii]
AID - 10.1016/j.jad.2011.11.007 [doi]
PST - ppublish
SO  - J Affect Disord. 2012 Feb;136(3):425-9. doi: 10.1016/j.jad.2011.11.007. Epub 2011 
      Dec 16.