PMID- 22178541
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20120123
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 16
IP  - 2
DP  - 2012 Feb
TI  - Human herpesvirus 6 in donor biopsies associated with the incidence of clinical 
      cytomegalovirus disease and hepatitis C virus recurrence.
PG  - e124-9
LID - 10.1016/j.ijid.2011.10.008 [doi]
AB  - BACKGROUND: Reactivation of cytomegalovirus (CMV) and human herpesvirus 6 
      (HHV-6), as well as the recurrence of hepatitis C virus (HCV), occurs in the post 
      liver transplantation period. However, their correlations remain questionable. 
      The objectives of this study were to analyze the presence of CMV DNA and HHV-6 
      DNA in pre-transplant and post-transplant liver graft biopsies and to determine 
      any correlations with CMV disease and HCV recurrence. METHODS: Forty-one liver 
      transplant recipients were followed up in the post-transplant period. The 
      presence of CMV DNA and HHV-6 DNA was detected by nested PCR. RESULTS: Four 
      patients (4/41, 9.8%) were positive for CMV DNA in pre-transplant biopsies and 
      three of them remained positive after transplantation; 11 patients became 
      positive in the post-transplant biopsies (p=0.06). Fifteen (15/41, 36.6%) 
      patients were positive for HHV-6 DNA in pre-transplant biopsies and 11 of these 
      remained positive after transplantation. Another 11 patients became positive 
      after the surgery (p=0.05). CMV disease occurred in 17 recipients; 10 of these 17 
      (58.8%) patients were positive for HHV-6 DNA in pre-transplant biopsies and they 
      continued positive after transplantation (p=0.0128). Twenty-eight patients were 
      transplanted due to hepatitis C; 12 of these patients had recurrence of the 
      virus, and HHV-6 was positive in nine of the 12 (75%) patients (p=0.049). 
      CONCLUSIONS: Recipients with HHV-6 DNA in pre-transplant graft biopsies remained 
      positive post transplantation, showing a possible risk for post-transplant 
      allograft loss because there was an association between HHV-6 and recurrent HCV 
      and CMV disease.
CI  - Copyright (c) 2011 International Society for Infectious Diseases. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Guardia, Ana Carolina
AU  - Guardia AC
AD  - Faculty of Medical Science, State University of Campinas, Campinas, Brazil.
FAU - Stucchi, Raquel Silveira Bello
AU  - Stucchi RS
FAU - Sampaio, Ana Maria
AU  - Sampaio AM
FAU - Milan, Arlete
AU  - Milan A
FAU - Costa, Sandra Cecilia Botelho
AU  - Costa SC
FAU - Pavan, Celia Regina
AU  - Pavan CR
FAU - Boin, Ilka de Fatima Santana Ferreira
AU  - Boin Ide F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111216
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biopsy/methods
MH  - Cohort Studies
MH  - Cytomegalovirus/genetics/*isolation & purification
MH  - Cytomegalovirus Infections/*epidemiology/genetics/virology
MH  - Female
MH  - Follow-Up Studies
MH  - Hepacivirus/*isolation & purification
MH  - Hepatitis C/*epidemiology/genetics/virology
MH  - Herpesviridae Infections/virology
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Humans
MH  - Incidence
MH  - Liver Transplantation/*adverse effects
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Tissue Donors
MH  - Transplantation, Homologous/adverse effects
MH  - Young Adult
EDAT- 2011/12/20 06:00
MHDA- 2012/08/21 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/07/15 00:00 [received]
PHST- 2011/10/17 00:00 [revised]
PHST- 2011/10/22 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - S1201-9712(11)00226-8 [pii]
AID - 10.1016/j.ijid.2011.10.008 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2012 Feb;16(2):e124-9. doi: 10.1016/j.ijid.2011.10.008. Epub 
      2011 Dec 16.