PMID- 22179051
OWN - NLM
STAT- MEDLINE
DCOM- 20120829
LR  - 20181201
IS  - 1546-8364 (Electronic)
IS  - 1059-8405 (Linking)
VI  - 28
IP  - 3
DP  - 2012 Jun
TI  - Is acanthosis nigricans a reliable indicator for risk of type 2 diabetes in obese 
      children and adolescents? A systematic review.
PG  - 195-205
LID - 10.1177/1059840511430952 [doi]
AB  - Obesity and type 2 diabetes is becoming a major health problem affecting children 
      and adolescents in the United States. This article reviews the current literature 
      examining the association between the presence of acanthosis nigricans (AN) and 
      risk for developing type 2 diabetes mellitus (T2DM) in obese children and 
      adolescents. Ethnicity, family history of diabetes, and emergence of obesity are 
      contributing factors for development of hyperinsulinemia, and insulin resistance, 
      and ensuing visible changes on skin which is known as the AN. The purpose of this 
      review was to assess the validity of AN as an early indicator of T2DM. Nineteen 
      articles that were published from 1994 to 2010 were included for this review and 
      reported an association between AN, hyperinsulinemia, and hyperglycemia. Nurses 
      and advanced nurse practitioners working with children and adolescents have a 
      tremendous role in identifying the risk factors, counseling, role modeling, and 
      referring them to available community resources to promote healthy living. Early 
      initiatives focusing on lifestyle changes may halt the progress, chronicity, and 
      burden of T2DM in children and adolescents.
FAU - Abraham, Cilymol
AU  - Abraham C
AD  - Harris County Hospital District, Pasadena, TX 77504, USA.
FAU - Rozmus, Cathy L
AU  - Rozmus CL
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20111216
PL  - United States
TA  - J Sch Nurs
JT  - The Journal of school nursing : the official publication of the National 
      Association of School Nurses
JID - 9206498
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
MH  - Acanthosis Nigricans/*diagnosis/epidemiology/etiology
MH  - Adolescent
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Child
MH  - Child, Preschool
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis/epidemiology
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Obesity/epidemiology
MH  - Risk Assessment
MH  - Risk Factors
MH  - United States/epidemiology
MH  - Young Adult
EDAT- 2011/12/20 06:00
MHDA- 2012/08/30 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/08/30 06:00 [medline]
AID - 1059840511430952 [pii]
AID - 10.1177/1059840511430952 [doi]
PST - ppublish
SO  - J Sch Nurs. 2012 Jun;28(3):195-205. doi: 10.1177/1059840511430952. Epub 2011 Dec 
      16.