PMID- 22179186
OWN - NLM
STAT- MEDLINE
DCOM- 20120412
LR  - 20211021
IS  - 1860-1499 (Electronic)
IS  - 1860-1499 (Linking)
VI  - 44
IP  - 4
DP  - 2011 Dec
TI  - Acquired cystic disease-associated renal cell carcinoma: an immunohistochemical 
      and fluorescence in situ hybridization study.
PG  - 228-32
LID - 10.1007/s00795-010-0496-1 [doi]
AB  - Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) has been 
      recently identified. However, there are only a few genetic studies to date. In 
      this article, we performed an immunohistochemical and fluorescence in situ 
      hybridization (FISH) study for six cases including one case with sarcomatoid 
      change. As a result, we observed frequent immunohistochemical expression of 
      AMACR. FISH of chromosome 3 showed trisomy for three cases, monosomy for two 
      cases, and disomy for one case. Additionally, FISH of chromosome 16 showed 
      trisomy for three cases, monosomy for two cases, and both trisomy and monosomy 
      for one case. Furthermore, both the carcinomatous area and the sarcomatoid area 
      of one ACD-associated RCC with sarcomatoid change revealed monosomy of 
      chromosomes 3, 9, and 16 but showed disomy of chromosome 14. In conclusion, the 
      numerical abnormalities of chromosomes 3 and 16, irrespective of gain or loss, 
      may be characteristic of ACD-associated RCC.
FAU - Kuroda, Naoto
AU  - Kuroda N
AD  - Department of Diagnostic Pathology, Kochi Red Cross Hospital, Shin-honmachi, 
      Kochi, Japan. kurochankochi@yahoo.co.jp
FAU - Yamashita, Motoki
AU  - Yamashita M
FAU - Kakehi, Yoshiyuki
AU  - Kakehi Y
FAU - Hes, Ondrej
AU  - Hes O
FAU - Michal, Michal
AU  - Michal M
FAU - Lee, Gang-Hong
AU  - Lee GH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111217
PL  - Japan
TA  - Med Mol Morphol
JT  - Medical molecular morphology
JID - 101239023
RN  - 0 (Keratin-7)
RN  - 0 (PAX2 Transcription Factor)
RN  - 0 (PAX2 protein, human)
RN  - EC 5.1.- (Racemases and Epimerases)
RN  - EC 5.1.99.4 (alpha-methylacyl-CoA racemase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aneuploidy
MH  - Carcinoma, Renal Cell/genetics/*metabolism/pathology
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 16/genetics
MH  - Chromosomes, Human, Pair 3/genetics
MH  - Chromosomes, Human, Pair 9/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Keratin-7/metabolism
MH  - Kidney Diseases, Cystic/genetics/*metabolism/pathology
MH  - Kidney Neoplasms/genetics/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Mitochondria/metabolism
MH  - PAX2 Transcription Factor/metabolism
MH  - Racemases and Epimerases/metabolism
EDAT- 2011/12/20 06:00
MHDA- 2012/04/13 06:00
CRDT- 2011/12/20 06:00
PHST- 2009/12/02 00:00 [received]
PHST- 2010/01/18 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/04/13 06:00 [medline]
AID - 10.1007/s00795-010-0496-1 [doi]
PST - ppublish
SO  - Med Mol Morphol. 2011 Dec;44(4):228-32. doi: 10.1007/s00795-010-0496-1. Epub 2011 
      Dec 17.