PMID- 22180175
OWN - NLM
STAT- MEDLINE
DCOM- 20120629
LR  - 20171206
IS  - 1724-6008 (Electronic)
IS  - 0393-6155 (Linking)
VI  - 26
IP  - 4
DP  - 2011 Oct-Dec
TI  - KIR/HLA combination associated with the risk of complications in celiac disease.
PG  - 221-8
LID - 10.5301/JBM.2011.8903 [doi]
AB  - The pathogenesis of celiac disease (CD) is associated with polymorphisms in human 
      leukocyte antigen (HLA) genes; however, compelling evidence suggests that 
      additional non-HLA genes are associated with CD and related complications. The 
      present study investigated whether killer cell immunoglobulin-like receptor 
      (KIR)/HLA gene combinations are associated with CD and its clinical complications 
      in the population of northeast Italy. The study included 61 adults affected by 
      CD: 48 patients were at first diagnosis and 13 patients had CD-related 
      complications (8 with refractory CD and 5 with cancer). Controls were 69 blood 
      donors genotyped for KIR and HLA. Several statistically significant differences 
      emerged between CD patients and blood donors. The results herein presented show 
      that susceptibility to CD with refractory disease or cancer is associated with 
      various genotypes including the 2DS2/2DL2+C1, 2DS3, 3DL1, and 2DL5B genes. In 
      addition, the absence of the Bw4 ligand may be a predisposing factor for cancer. 
      These results suggest that a KIR haplotype and HLA ligands may be involved in the 
      susceptibility to important clinical CD complications such as tumors or 
      refractoriness as a result of a gluten-free diet.
FAU - Caggiari, Laura
AU  - Caggiari L
AD  - Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico, 
      IRCCS, National Cancer Institute, Aviano - Italy.
FAU - Toffoli, Giuseppe
AU  - Toffoli G
FAU - De Re, Valli
AU  - De Re V
FAU - Orzes, Nicoletta
AU  - Orzes N
FAU - Spina, Michele
AU  - Spina M
FAU - De Zorzi, Mariangela
AU  - De Zorzi M
FAU - Maiero, Stefania
AU  - Maiero S
FAU - Cannizzaro, Renato
AU  - Cannizzaro R
FAU - Canzonieri, Vincenzo
AU  - Canzonieri V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Biol Markers
JT  - The International journal of biological markers
JID - 8712411
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Celiac Disease/*genetics/immunology/pathology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Receptors, KIR/*genetics/immunology
MH  - Young Adult
EDAT- 2011/12/20 06:00
MHDA- 2012/06/30 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/09/09 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/06/30 06:00 [medline]
AID - 20BD90CB-5D66-485F-A7E9-D9F974CAE946 [pii]
AID - 10.5301/JBM.2011.8903 [doi]
PST - ppublish
SO  - Int J Biol Markers. 2011 Oct-Dec;26(4):221-8. doi: 10.5301/JBM.2011.8903.