PMID- 22182340
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20191210
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 106
IP  - 3
DP  - 2012 Mar
TI  - Predictors of benefit following pulmonary rehabilitation for interstitial lung 
      disease.
PG  - 429-35
LID - 10.1016/j.rmed.2011.11.014 [doi]
AB  - BACKGROUND: Pulmonary rehabilitation improves functional capacity and symptoms in 
      the interstitial lung diseases (ILDs), however there is marked variation in 
      outcomes between individuals. The aim of this study was to establish the impact 
      of the aetiology and severity of ILD on response to pulmonary rehabilitation. 
      METHODS: Forty-four subjects with ILD, including 25 with idiopathic pulmonary 
      fibrosis (IPF), underwent eight weeks of pulmonary rehabilitation. Relationships 
      between disease aetiology, markers of disease severity and response to pulmonary 
      rehabilitation were assessed after eight weeks and six months, regardless of 
      program completion. RESULTS: In IPF, greater improvements in 6-minute walk 
      distance (6MWD) immediately following pulmonary rehabilitation were associated 
      with larger forced vital capacity (r = 0.49, p = 0.01), less exercise-induced 
      oxyhaemoglobin desaturation (r(S) = 0.43, p = 0.04) and lower right ventricular 
      systolic pressure (r = -0.47, p = 0.1). In participants with other ILDs there was 
      no relationship between change in 6MWD and baseline variables. Less 
      exercise-induced oxyhaemoglobin desaturation at baseline independently predicted 
      a larger improvement in 6MWD at six month follow-up. Fewer participants with IPF 
      had clinically important reductions in dyspnoea at six months compared to those 
      with other ILDs (25% vs 56%, p = 0.04). More severe dyspnoea at baseline and 
      diagnosis other than IPF predicted greater improvement in dyspnoea at six months. 
      CONCLUSIONS: Patients with IPF attain greater and more sustained benefits from 
      pulmonary rehabilitation when disease is mild, whereas those with other ILDs 
      achieve benefits regardless of disease severity. Early referral to pulmonary 
      rehabilitation should be considered in IPF.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Holland, Anne E
AU  - Holland AE
AD  - Physiotherapy, Alfred Health, VIC 3004, Australia. a.holland@alfred.org.au
FAU - Hill, Catherine J
AU  - Hill CJ
FAU - Glaspole, Ian
AU  - Glaspole I
FAU - Goh, Nicole
AU  - Goh N
FAU - McDonald, Christine F
AU  - McDonald CF
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20111217
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Oxyhemoglobins)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Dyspnea/etiology/physiopathology/rehabilitation
MH  - Exercise Test/methods
MH  - Follow-Up Studies
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/physiopathology/rehabilitation
MH  - Lung Diseases, Interstitial/etiology/physiopathology/*rehabilitation
MH  - Middle Aged
MH  - Oxygen/blood
MH  - Oxyhemoglobins/metabolism
MH  - Partial Pressure
MH  - Prognosis
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Vital Capacity/physiology
MH  - Walking/physiology
EDAT- 2011/12/21 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/12/21 06:00
PHST- 2011/07/15 00:00 [received]
PHST- 2011/11/04 00:00 [revised]
PHST- 2011/11/27 00:00 [accepted]
PHST- 2011/12/21 06:00 [entrez]
PHST- 2011/12/21 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - S0954-6111(11)00435-5 [pii]
AID - 10.1016/j.rmed.2011.11.014 [doi]
PST - ppublish
SO  - Respir Med. 2012 Mar;106(3):429-35. doi: 10.1016/j.rmed.2011.11.014. Epub 2011 
      Dec 17.