PMID- 22183424
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20171116
IS  - 1529-0131 (Electronic)
IS  - 0004-3591 (Linking)
VI  - 64
IP  - 6
DP  - 2012 Jun
TI  - Association of anticytomegalovirus seropositivity with more severe joint 
      destruction and more frequent joint surgery in rheumatoid arthritis.
PG  - 1740-9
LID - 10.1002/art.34346 [doi]
AB  - OBJECTIVE: Expansion of autoreactive CD4+CD28(null) T cells is associated with 
      extraarticular disease manifestations, including rheumatoid vasculitis, and it 
      has recently been demonstrated that expansion of these T cells is associated with 
      anticytomegalovirus (anti-CMV) seropositivity. This study was undertaken to 
      investigate a possible link between latent CMV infection and rheumatoid arthritis 
      (RA). METHODS: In a retrospective analysis, anti-CMV antibodies and clinical, 
      serologic, and radiologic parameters of joint destruction were examined in 202 RA 
      patients and 272 healthy controls. In addition, frequencies of CD4+CD28(null) T 
      cells; concentrations of the cytokines monocyte chemotactic protein 1 (MCP-1), 
      interferon-alpha (IFNalpha), and IFN-inducible protein 10; and anti-CMV-specific T cell 
      responses were analyzed in RA patients. RESULTS: Overall, no significant 
      difference in the frequency of anti-CMV seropositivity between RA patients and 
      healthy controls was observed. Among individuals older than age 55 years, 
      however, anti-CMV IgG antibodies were significantly more frequent in RA patients 
      than controls (65.3% and 54.7%, respectively; P = 0.05). Anti-CMV seropositivity 
      in RA patients was associated with an increased frequency of CD4+CD28(null) T 
      cells and increased serum concentrations of MCP-1. The frequency of 
      anti-CMV-specific CD4+ T cells producing IFNgamma was increased in RA patients 
      compared to controls. Most importantly, anti-CMV-seropositive RA patients showed 
      radiographic evidence of more advanced joint destruction and had increased 
      frequencies of joint-related surgical procedures, indicating more severe joint 
      disease. CONCLUSION: Our findings indicate that latent CMV infection aggravates 
      the clinical course of RA and is associated with increased frequencies of 
      CD4+CD28(null) T cells and of CMV-specific IFNgamma-secreting CD4+ T cells.
CI  - Copyright (c) 2012 by the American College of Rheumatology.
FAU - Pierer, Matthias
AU  - Pierer M
AD  - University of Leipzig, Leipzig, Germany.
FAU - Rothe, Kathrin
AU  - Rothe K
FAU - Quandt, Dagmar
AU  - Quandt D
FAU - Schulz, Anett
AU  - Schulz A
FAU - Rossol, Manuela
AU  - Rossol M
FAU - Scholz, Roger
AU  - Scholz R
FAU - Baerwald, Christoph
AU  - Baerwald C
FAU - Wagner, Ulf
AU  - Wagner U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111219
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (CD28 Antigens)
RN  - 0 (Chemokine CCL2)
SB  - IM
CIN - Arthritis Rheum. 2012 Aug;64(8):2803-4; author reply 2804-5. PMID: 22605517
MH  - Aged
MH  - Arthritis, Rheumatoid/complications/*immunology/pathology/surgery
MH  - CD28 Antigens/immunology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Chemokine CCL2/blood
MH  - Cytomegalovirus/*immunology
MH  - Cytomegalovirus Infections/complications/*immunology/pathology
MH  - Female
MH  - Humans
MH  - Joints/*pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 2011/12/21 06:00
MHDA- 2012/08/14 06:00
CRDT- 2011/12/21 06:00
PHST- 2011/12/21 06:00 [entrez]
PHST- 2011/12/21 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - 10.1002/art.34346 [doi]
PST - ppublish
SO  - Arthritis Rheum. 2012 Jun;64(6):1740-9. doi: 10.1002/art.34346. Epub 2011 Dec 19.