PMID- 22186115
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20180614
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Linking)
VI  - 47
IP  - 10
DP  - 2011
TI  - Human herpesvirus 6 and 7 reactivation and disease activity in multiple 
      sclerosis.
PG  - 527-31
AB  - Recent studies have focused on the associations between human herpesvirus 6 
      (HHV-6) and human herpesvirus 7 (HHV-7), and multiple sclerosis (MS). The aim of 
      this study was to investigate the associations between HHV-6 and HHV-7 
      reactivation and MS disease activity, and interleukin 12 (IL-12) and tumor 
      necrosis factor alpha (TNF-alpha) production. MATERIAL AND METHODS: The frequency of 
      plasma viremia by nested polymerase chain reaction and transcription of viral 
      mRNA in peripheral blood mononuclear cells by reverse transcriptase-polymerase 
      chain reaction (RT-PCR) of 14 relapsing/remitting (RR) and 14 secondary 
      progressive (SP) MS patients were studied in comparison with clinical 
      manifestation of the disease. Serum concentrations of cytokines IL-12 and TNF-alpha 
      were analyzed by enzyme-linked immunosorbent assay. RESULTS: Plasma samples from 
      25 of the 28 MS patients with estimated latent/persistent HHV-6 and/or HHV-7 
      infection were examined during relapse and remission/relative remission. HHV-6 
      reactivation was found in 4 of the 7 RRMS and 4 of the 7 SPMS patients, and HHV-7 
      reactivation was identified in 3 of the 7 RRMS and 1 of the 7 SPMS patients (all 
      in relapse). In 2 of the 3 RRMS patients without viremia in relapse, HHV-6 mRNA 
      transcription was detected. In RRMS and SPMS patients with active HHV-6 and HHV-7 
      infection in relapse, the serum concentrations of IL-12 and TNF-alpha were 
      significantly higher than in those with latent virus infection. CONCLUSIONS: 
      HHV-6 and HHV-7 reactivation could be implicated in the exacerbation of MS via 
      activation of Th1 lymphocyte subsets.
FAU - Nora-Krukle, Zaiga
AU  - Nora-Krukle Z
AD  - August Kirchenstein Institute of Microbiology and Virology, Riga Stradins 
      University, Latvia. zaiga.nora@gmail.com
FAU - Chapenko, Svetlana
AU  - Chapenko S
FAU - Logina, Inara
AU  - Logina I
FAU - Millers, Andrejs
AU  - Millers A
FAU - Platkajis, Ardis
AU  - Platkajis A
FAU - Murovska, Modra
AU  - Murovska M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Disease Progression
MH  - Female
MH  - Herpesvirus 6, Human/isolation & purification/*physiology
MH  - Herpesvirus 7, Human/isolation & purification/*physiology
MH  - Humans
MH  - Interleukin-12/blood
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/blood/*immunology/*virology
MH  - Roseolovirus Infections/complications/*virology
MH  - Th1 Cells/immunology
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Viremia/complications/diagnosis/virology
MH  - *Virus Activation
MH  - Young Adult
EDAT- 2011/12/22 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 1110-01e [pii]
PST - ppublish
SO  - Medicina (Kaunas). 2011;47(10):527-31.