PMID- 22187527
OWN - NLM
STAT- MEDLINE
DCOM- 20120628
LR  - 20211021
IS  - 1110-7251 (Electronic)
IS  - 1110-7243 (Print)
IS  - 1110-7243 (Linking)
VI  - 2011
DP  - 2011
TI  - Localization of Magic-F1 transgene, involved in muscular hypertrophy, during 
      early myogenesis.
PG  - 492075
LID - 10.1155/2011/492075 [doi]
LID - 492075
AB  - We recently showed that Magic-F1 (Met-activating genetically improved chimeric 
      factor 1), a human recombinant protein derived from hepatocyte growth 
      factor/scatter factor (HGF/SF) induces muscle cell hypertrophy but not progenitor 
      cell proliferation, both in vitro and in vivo. Here, we examined the temporal and 
      spatial expression pattern of Magic-F1 in comparison with Pax3 (paired box gene 
      3) transcription factor during embryogenesis. Ranging from 9.5 to 17.5 dpc (days 
      post coitum) mouse embryos were analyzed by in situ hybridization using whole 
      mounts during early stages of development (9.5-10.5-11.5 dpc) and cryostat 
      sections for later stages (11.5-13.5-15.5-17.5 dpc). We found that Magic-F1 is 
      expressed in developing organs and tissues of mesenchymal origin, where Pax3 
      signal appears to be downregulated respect to the wt embryos. These data suggest 
      that Magic-F1 could be responsible of muscular hypertrophy, cooperating with Pax3 
      signal pathway in skeletal muscle precursor cells.
FAU - Ronzoni, Flavio
AU  - Ronzoni F
AD  - Human Anatomy Section, University of Pavia, Via Forlanini 8, 27100 Pavia, Italy.
FAU - Bongio, Matilde
AU  - Bongio M
FAU - Conte, Silvio
AU  - Conte S
FAU - Vercesi, Luigi
AU  - Vercesi L
FAU - Cassano, Marco
AU  - Cassano M
FAU - Tribioli, Carla
AU  - Tribioli C
FAU - Galli, Daniela
AU  - Galli D
FAU - Bellazzi, Riccardo
AU  - Bellazzi R
FAU - Magenes, Giovanni
AU  - Magenes G
FAU - Cusella De Angelis, Maria Gabriella
AU  - Cusella De Angelis MG
FAU - Sampaolesi, Maurilio
AU  - Sampaolesi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111210
PL  - United States
TA  - J Biomed Biotechnol
JT  - Journal of biomedicine & biotechnology
JID - 101135740
RN  - 0 (PAX3 Transcription Factor)
RN  - 0 (Paired Box Transcription Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - 0 (magic-factor 1 protein, mouse)
RN  - 138016-91-8 (Pax3 protein, mouse)
SB  - IM
MH  - Animals
MH  - Embryo, Mammalian
MH  - Female
MH  - Gene Expression Profiling
MH  - Hypertrophy/genetics/metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Muscle, Skeletal/embryology/*pathology
MH  - Organ Specificity
MH  - PAX3 Transcription Factor
MH  - Paired Box Transcription Factors/analysis/genetics/metabolism
MH  - Polymerase Chain Reaction
MH  - Pregnancy
MH  - RNA, Messenger/analysis
MH  - Recombinant Proteins/analysis/*genetics/metabolism
PMC - PMC3237019
EDAT- 2011/12/22 06:00
MHDA- 2012/06/29 06:00
PMCR- 2011/12/10
CRDT- 2011/12/22 06:00
PHST- 2011/05/31 00:00 [received]
PHST- 2011/09/14 00:00 [revised]
PHST- 2011/09/19 00:00 [accepted]
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/06/29 06:00 [medline]
PHST- 2011/12/10 00:00 [pmc-release]
AID - 10.1155/2011/492075 [doi]
PST - ppublish
SO  - J Biomed Biotechnol. 2011;2011:492075. doi: 10.1155/2011/492075. Epub 2011 Dec 
      10.