PMID- 22188715
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20191112
IS  - 1349-3299 (Electronic)
IS  - 1349-2365 (Linking)
VI  - 52
IP  - 6
DP  - 2011
TI  - Combined effect of disopyramide and erythromycin on ventricular repolarization in 
      dogs with complete atrioventricular block.
PG  - 393-7
AB  - The combined effects of disopyramide (DP) and erythromycin (EM) on ventricular 
      repolarization and the inciden-ces of ventricular premature contractions (VPCs) 
      and torsades de pointes (TdP) were investigated in 12 anesthetized dogs with 
      complete atrioventricular block. Monophasic action potentials (MAPs) were 
      measured from the left and right ventricular (LV and RV) endocardium. The right 
      or left ventricle was paced at a cycle length of 750-1000 msec. Dogs were divided 
      into 2 groups and given either intravenous DP at 3 mg/kg and then intravenous EM 
      at 50 mg/kg (group 1, n = 8), or intravenous EM at 50 mg/kg and then intravenous 
      DP at 3 mg/kg (group 2, n = 4). MAP duration at 90% repolarization (MAPD(90)) was 
      measured before drug administration (baseline) and again after administration of 
      each drug. RV MAPD(90) and LV MAPD(90) increased significantly (P < 0.02) after 
      administration of each drug in group 1 (RV MAPD(90): from 247.0 +/- 36.3 [baseline] 
      to 283.5 +/- 38.3 to 321.8 +/- 56.7; LV MAPD(90): from 262.6 +/- 49.1 (baseline) to 
      296.1 +/- 58.8 to 351.0 +/- 80.6). Early afterdepolarizations developed in 2 group 1 
      dogs after administration of DP and in 4 additional dogs after administration of 
      EM. Frequent VPCs occurred in 1 dog after administration of DP and in 2 
      additional dogs after administration of EM, and TdP and ventricular tachycardias 
      developed in 2 of the 3 dogs after administration of EM. Similar trends occurred 
      in group 2. These results indicate a potentially fatal interaction between DP and 
      EM administered in clinically relevant doses.
FAU - Watanabe, Ichiro
AU  - Watanabe I
AD  - Division of Cardiology, Department of Medicine, Nihon University School of 
      Medicine, Tokyo, Japan.
FAU - Okumura, Yasuo
AU  - Okumura Y
FAU - Nagashima, Koichi
AU  - Nagashima K
FAU - Kofune, Masayoshi
AU  - Kofune M
FAU - Ohkubo, Kimie
AU  - Ohkubo K
FAU - Mano, Hiroaki
AU  - Mano H
FAU - Sonoda, Kazumasa
AU  - Sonoda K
FAU - Kasamaki, Yuji
AU  - Kasamaki Y
FAU - Hirayama, Atsushi
AU  - Hirayama A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Int Heart J
JT  - International heart journal
JID - 101244240
RN  - 0 (Anti-Arrhythmia Agents)
RN  - 0 (Protein Synthesis Inhibitors)
RN  - 63937KV33D (Erythromycin)
RN  - GFO928U8MQ (Disopyramide)
SB  - IM
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Anti-Arrhythmia Agents/administration & dosage
MH  - Atrioventricular Block/*drug therapy/physiopathology
MH  - Disease Models, Animal
MH  - Disopyramide/*administration & dosage
MH  - Dogs
MH  - Dose-Response Relationship, Drug
MH  - Drug Therapy, Combination
MH  - Electrocardiography/*drug effects
MH  - Erythromycin/*administration & dosage
MH  - Heart Conduction System/*drug effects/physiopathology
MH  - Prognosis
MH  - Protein Synthesis Inhibitors/administration & dosage
MH  - Ventricular Function/*drug effects
EDAT- 2011/12/23 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/12/23 06:00
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - JST.JSTAGE/ihj/52.393 [pii]
AID - 10.1536/ihj.52.393 [doi]
PST - ppublish
SO  - Int Heart J. 2011;52(6):393-7. doi: 10.1536/ihj.52.393.