PMID- 22189045
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20211021
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 120
IP  - 4
DP  - 2012 Apr
TI  - Environmental exposure to polychlorinated biphenyls and p,p'-DDE and sperm 
      sex-chromosome disomy.
PG  - 535-40
LID - 10.1289/ehp.1104017 [doi]
AB  - BACKGROUND: Chromosomal abnormalities contribute substantially to reproductive 
      problems, but the role of environmental risk factors has received little 
      attention. OBJECTIVES: We evaluated the association of polychlorinated biphenyl 
      (PCB) and dichlorodiphenyldichloroethylene (p,p'-DDE) exposures with sperm 
      sex-chromosome disomy. METHODS: We conducted a cross-sectional study of 192 men 
      from subfertile couples. We used multiprobe fluorescence in situ hybridization 
      (FISH) for chromosomes X, Y, and 18 to determine XX, YY, XY, and total 
      sex-chromosome disomy in sperm nuclei. Serum was analyzed for concentrations of 
      57 PCB congeners and p,p'-DDE. Poisson regression models were used to calculate 
      incidence rate ratios (IRRs) for disomy by exposure quartiles, controlling for 
      demographic characteristics and semen parameters. RESULTS: The median percent 
      disomy was 0.3 for XX and YY, 0.9 for XY, and 1.6 for total sex-chromosome 
      disomy. We observed a significant trend of increasing IRRs for increasing 
      quartiles of p,p'-DDE in XX, XY, and total sex-chromosome disomy, and a 
      significant trend of increasing IRRs for increasing quartiles of PCBs for XY and 
      total sex-chromosome disomy; however, there was a significant inverse association 
      for XX disomy. CONCLUSIONS: Our findings suggest that exposure to p,p'-DDE may be 
      associated with increased rates of XX, XY, and total sex-chromosome disomy, 
      whereas exposure to PCBs may be associated with increased rates of YY, XY, and 
      total sex-chromosome disomy. In addition, we observed an inverse association 
      between increased exposure to PCBs and XX disomy. Further work is needed to 
      confirm these findings.
FAU - McAuliffe, Megan E
AU  - McAuliffe ME
AD  - Department of Environmental Health, Harvard School of Public Health, Boston, 
      Massachusetts, USA.
FAU - Williams, Paige L
AU  - Williams PL
FAU - Korrick, Susan A
AU  - Korrick SA
FAU - Altshul, Larisa M
AU  - Altshul LM
FAU - Perry, Melissa J
AU  - Perry MJ
LA  - eng
GR  - R01 ES017457/ES/NIEHS NIH HHS/United States
GR  - T42 OH008416/OH/NIOSH CDC HHS/United States
GR  - P30 ES000002/ES/NIEHS NIH HHS/United States
GR  - ES 009718/ES/NIEHS NIH HHS/United States
GR  - R01 ES009718/ES/NIEHS NIH HHS/United States
GR  - ES 000002/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111221
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - *Aneuploidy
MH  - Chromosomes, Human, Y/*drug effects
MH  - Cross-Sectional Studies
MH  - Dichlorodiphenyl Dichloroethylene/blood/*toxicity
MH  - *Environmental Exposure
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Massachusetts
MH  - Poisson Distribution
MH  - Polychlorinated Biphenyls/blood/*toxicity
MH  - Regression Analysis
MH  - Sex Chromosome Aberrations/*chemically induced
MH  - Spermatozoa/cytology/drug effects
PMC - PMC3339457
COIS- The authors' freedom to design, conduct, interpret, and publish research is not 
      compromised by any controlling sponsor as a condition of review or publication. 
      L.A. is employed by Environmental Health and Engineering Inc. The authors declare 
      they have no actual or potential competing financial interests.
EDAT- 2011/12/23 06:00
MHDA- 2012/08/01 06:00
PMCR- 2012/04/01
CRDT- 2011/12/23 06:00
PHST- 2011/05/31 00:00 [received]
PHST- 2011/12/21 00:00 [accepted]
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - ehp.1104017 [pii]
AID - 10.1289/ehp.1104017 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2012 Apr;120(4):535-40. doi: 10.1289/ehp.1104017. Epub 
      2011 Dec 21.