PMID- 22189295
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20120109
IS  - 1879-2448 (Electronic)
IS  - 0043-1354 (Linking)
VI  - 46
IP  - 3
DP  - 2012 Mar 1
TI  - Fate of steroid hormones and endocrine activities in swine manure disposal and 
      treatment facilities.
PG  - 895-906
LID - 10.1016/j.watres.2011.11.074 [doi]
AB  - Manure may contain high concern endocrine-disrupting compounds (EDCs) such as 
      steroid hormones, naturally produced by pigs, which are present at mugL(-1) 
      levels. Manure may also contain other EDCs such as nonylphenols (NP), polycyclic 
      aromatic hydrocarbons (PAHs) and dioxins. Thus, once manure is applied to the 
      land as soil fertilizer these compounds may reach aquifers and consequently 
      living organisms, inducing abnormal endocrine responses. In France, manure is 
      generally stored in anaerobic tanks prior spreading on land; when nitrogen 
      removal is requested, manure is treated by aerobic processes before spreading. 
      However, little is known about the fate of hormones and multiple 
      endocrine-disrupting activities in such manure disposal and treatment systems. 
      Here, we determined the fate of hormones and diverse endocrine activities during 
      manure storage and treatment by combining chemical analysis and in vitro 
      quantification of estrogen (ER), aryl hydrocarbon (AhR), androgen (AR), 
      pregnane-X (PXR) and peroxysome proliferator-activated gamma (PPARgamma) 
      receptor-mediated activities. Our results show that manure contains large 
      quantities of hormones and activates ER and AhR, two of the nuclear receptors 
      studied. Most of these endocrine activities were found in the solid fraction of 
      manure and appeared to be induced mainly by hormones and other unidentified 
      pollutants. Hormones, ER and AhR activities found in manure were poorly removed 
      during manure storage but were efficiently removed by aerobic treatment of 
      manure.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Combalbert, Sarah
AU  - Combalbert S
AD  - INRA, UR050 Laboratoire de Biotechnologie de l'Environnement, Avenue des Etangs, 
      F-11100 Narbonne, France.
FAU - Bellet, Virginie
AU  - Bellet V
FAU - Dabert, Patrick
AU  - Dabert P
FAU - Bernet, Nicolas
AU  - Bernet N
FAU - Balaguer, Patrick
AU  - Balaguer P
FAU - Hernandez-Raquet, Guillermina
AU  - Hernandez-Raquet G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111208
PL  - England
TA  - Water Res
JT  - Water research
JID - 0105072
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Hormones)
RN  - 0 (Manure)
RN  - 0 (Steroids)
SB  - IM
MH  - Aerobiosis
MH  - Animals
MH  - Cell Line
MH  - Ecotoxicology
MH  - Endocrine Disruptors/*analysis
MH  - France
MH  - Hormones/*analysis
MH  - Humans
MH  - Manure/*analysis
MH  - Refuse Disposal/*methods
MH  - Steroids/*analysis
MH  - Swine
EDAT- 2011/12/23 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/12/23 06:00
PHST- 2011/07/25 00:00 [received]
PHST- 2011/11/29 00:00 [revised]
PHST- 2011/11/30 00:00 [accepted]
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - S0043-1354(11)00766-4 [pii]
AID - 10.1016/j.watres.2011.11.074 [doi]
PST - ppublish
SO  - Water Res. 2012 Mar 1;46(3):895-906. doi: 10.1016/j.watres.2011.11.074. Epub 2011 
      Dec 8.