PMID- 22190530
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20220327
IS  - 1008-9292 (Print)
IS  - 1008-9292 (Linking)
VI  - 40
IP  - 6
DP  - 2011 Nov
TI  - [Effects of proton pump inhibitors on in-stent restenosis in patients receiving 
      clopidogrel: a retrospective analysis].
PG  - 667-72
AB  - OBJECTIVE: To determine the effect of proton pump inhibitor (PPI) on in-stent 
      restenosis (ISR) in patients receiving clopidogrel therapy. METHODS: Total 439 
      patients underwent percutaneous coronary intervention (PCI) were enrolled in the 
      study,including 250 post-PCI patients discharged on clopidogrel alone and 189 
      patients discharged on clopidogrel with PPI. The in-stent restenosis (ISR) ratio 
      of the patients in these two groups were observed. RESULTS: During a mean 
      follow-up period of (13 +/- 5.9) months, the post-PCI patients discharged on 
      concomitant clopidogrel-PPI therapy had higher risk of ISR than those discharged 
      on clopidogrel alone (19.6% Compared with 8%, P<0.001). CONCLUSION: Concomitant 
      use of clopidogrel and PPI after hospital discharge would increase the risk of 
      ISR for post-PCI patients.
FAU - Li, Zhan-lu
AU  - Li ZL
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, 
      Zhejiang University, Hangzhou 310016, China. alu520511@163.com
FAU - Zhou, Bin-quan
AU  - Zhou BQ
FAU - Zhu, Jun-hui
AU  - Zhu JH
FAU - Fu, Guo-sheng
AU  - Fu GS
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhejiang Da Xue Xue Bao Yi Xue Ban
JT  - Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical 
      sciences
JID - 100927946
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - A74586SNO7 (Clopidogrel)
RN  - OM90ZUW7M1 (Ticlopidine)
SB  - IM
MH  - Angioplasty, Balloon, Coronary
MH  - Clopidogrel
MH  - Coronary Restenosis/*etiology
MH  - Drug Antagonism
MH  - Drug Therapy, Combination
MH  - Follow-Up Studies
MH  - Humans
MH  - Platelet Aggregation Inhibitors/therapeutic use
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Retrospective Studies
MH  - Risk
MH  - Stents
MH  - Ticlopidine/*analogs & derivatives/therapeutic use
EDAT- 2011/12/23 06:00
MHDA- 2012/05/04 06:00
CRDT- 2011/12/23 06:00
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
AID - 10.3785/j.issn.1008-9292.2011.06.016 [doi]
PST - ppublish
SO  - Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Nov;40(6):667-72. doi: 
      10.3785/j.issn.1008-9292.2011.06.016.