PMID- 22190910
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1687-4765 (Electronic)
IS  - 1687-4757 (Print)
VI  - 2011
DP  - 2011
TI  - Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect 
      Induced by Peroxisome Proliferator-Activated Receptor gamma Agonist In Vivo.
PG  - 840194
LID - 10.1155/2011/840194 [doi]
LID - 840194
AB  - Peroxisome proliferator-activated receptor gamma (PPARgamma) forms a heterodimeric 
      DNA-binding complex with retinoid X receptors (RXRs). It has been reported that 
      the effect of the PPAR agonist is reduced in hepatocyte RXR-deficient mice. 
      Therefore, it is suggested that the endogenous RXR ligand is involved in the 
      PPARgamma agonist-induced anti-inflammatory effect. However, the participation of the 
      RXR ligand in the PPARgamma-induced anti-inflammatory effect is unknown. Here, we 
      investigated the influence of RXR antagonist on the anti-inflammatory effect of 
      PPARgamma agonist pioglitazone in carrageenan test. In addition, we also examined the 
      influence of PPAR antagonist on the anti-inflammatory effect induced by RXR 
      agonist NEt-3IP. The RXR antagonist suppressed the antiedema effect of PPARgamma 
      agonist. In addition, the anti-inflammatory effect of RXR agonist was suppressed 
      by PPARgamma antagonist. PPARgamma agonist-induced anti-inflammatory effects were 
      reversed by the RXR antagonist. Thus, we showed that the endogenous RXR ligand 
      might contribute to the PPARgamma agonist-induced anti-inflammatory effect.
FAU - Yamamoto, Atsuki
AU  - Yamamoto A
AD  - Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical 
      Sciences, Tsushima-naka 1-1-1, Kita-ku, Okayama 700-8530, Japan.
FAU - Kakuta, Hiroki
AU  - Kakuta H
FAU - Miyachi, Hiroyuki
AU  - Miyachi H
FAU - Sugimoto, Yukio
AU  - Sugimoto Y
LA  - eng
PT  - Journal Article
DEP - 20111211
PL  - United States
TA  - PPAR Res
JT  - PPAR research
JID - 101269101
PMC - PMC3236425
EDAT- 2011/12/23 06:00
MHDA- 2011/12/23 06:01
PMCR- 2011/12/11
CRDT- 2011/12/23 06:00
PHST- 2011/07/12 00:00 [received]
PHST- 2011/09/13 00:00 [accepted]
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2011/12/23 06:01 [medline]
PHST- 2011/12/11 00:00 [pmc-release]
AID - 10.1155/2011/840194 [doi]
PST - ppublish
SO  - PPAR Res. 2011;2011:840194. doi: 10.1155/2011/840194. Epub 2011 Dec 11.