PMID- 22192419
OWN - NLM
STAT- MEDLINE
DCOM- 20120507
LR  - 20221207
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 11
DP  - 2011 Dec 22
TI  - The odor stick identification test for Japanese differentiates Parkinson's 
      disease from multiple system atrophy and progressive supra nuclear palsy.
PG  - 157
LID - 10.1186/1471-2377-11-157 [doi]
AB  - BACKGROUND: Progressive supranuclear palsy (PSP) and parkinsonian variant of 
      multiple system atrophy (MSA-P) are clinically difficult to differentiate from 
      idiopathic Parkinson's disease (PD), particularly in the early stages of the 
      disease. Previous reports indicated that the olfactory function is relatively 
      intact or slightly reduced in patients with PSP and MSA-P, suggesting that the 
      odor stick identification test for Japanese (OSIT-J), which is a short and simple 
      noninvasive test that is potentially useful clinically for detecting early-stage 
      PD in Japan, may be useful in the differential diagnosis of early-stage PD from 
      MSA-P and PSP. There is no information on the sensitivity and specificity of 
      OSIT-J in the diagnosis of parkinsonian syndromes such as PSP and MSA-P. METHODS: 
      We assessed the olfactory function using the OSIT-J test in 94 Japanese patients 
      with idiopathic PD, 15 with MSA-P, 7 with PSP, and 29 age-matched control 
      subjects. RESULTS: The mean +/- SD score of OSIT-J in patients with PD (4.4 +/- 2.9) 
      was significantly lower than in patients with MSA-P (8.7 +/- 2.2, P < 0.0001), PSP 
      (7.6 +/- 2.2, P < 0.0057), and control subjects (10.5 +/- 1.3, P < 0.0001). The area 
      under the curve (AUC) of receiver operating characteristic (ROC) to discriminate 
      PD from normal control using OSIT-J scores was 0.97 (95% confidence interval, 
      0.95-1.00), from MSA-P 0.87 (0.80-0.95), and from PSP 0.81 (0.66-0.96). 
      CONCLUSION: The OSIT-J is a potentially useful clinical test not only for 
      detection of olfactory deficit in PD but also for differentiating PD from MSA-P 
      and PSP.
FAU - Suzuki, Masahiko
AU  - Suzuki M
AD  - Department of Neurology, Aoto Hospital, Jikei University School of Medicine, 
      6-41-2 Aoto Katsushika-ku, Tokyo 125-8506, Japan. suzukimd@jikei.ac.jp
FAU - Hashimoto, Masaya
AU  - Hashimoto M
FAU - Yoshioka, Masayuki
AU  - Yoshioka M
FAU - Murakami, Maiko
AU  - Murakami M
FAU - Kawasaki, Keiichi
AU  - Kawasaki K
FAU - Urashima, Mitsuyoshi
AU  - Urashima M
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111222
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
SB  - IM
MH  - Aged
MH  - Asian People
MH  - Diagnosis, Differential
MH  - Discriminant Analysis
MH  - Female
MH  - Humans
MH  - Male
MH  - Multiple System Atrophy/*diagnosis
MH  - Odorants/analysis
MH  - Olfaction Disorders/*diagnosis/*ethnology/etiology
MH  - Parkinson Disease/complications/*diagnosis
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - Supranuclear Palsy, Progressive/*diagnosis
PMC - PMC3297535
EDAT- 2011/12/24 06:00
MHDA- 2012/05/09 06:00
PMCR- 2011/12/22
CRDT- 2011/12/24 06:00
PHST- 2011/05/02 00:00 [received]
PHST- 2011/12/22 00:00 [accepted]
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
PHST- 2011/12/22 00:00 [pmc-release]
AID - 1471-2377-11-157 [pii]
AID - 10.1186/1471-2377-11-157 [doi]
PST - epublish
SO  - BMC Neurol. 2011 Dec 22;11:157. doi: 10.1186/1471-2377-11-157.